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Paclitaxel, 99.5+%

Product Code. 15495039
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Product Code. 15495039 Supplier Thermo Scientific Alfa Aesar Supplier No. J62734.MC
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Description

Paclitaxel (CAS # 33069-62-4) is a microtubule inhibitor produced from the extract of the Pacific yew tree. | CAS: 33069-62-4 | C47H51NO14 | 853.92 g/mol

Promotes assembly and inhibits disassembly of microtubules (anti-cancer agent)Paclitaxel is widely used in chemotherapeutic compound. It is used to treat certain types of cancer such as ovarian cancer, breast cancer, lung cancer and pancreatic cancer among others. It interferes with the growth of cancer cells and slows down their growth and spread in the body. It is also used to treat AIDS-related Kaposi's sarcoma.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Paclitaxel is a tetracyclic diterpenoid isolated from the Pacific yew, Taxus brevifolia
  • Paclitaxel acts as an antineoplastic agent by binding tubulin and preventing cell division
  • Paclitaxel may also bind Bcl-2 and lead to disinhibition of apoptosis

Application

  • Paclitaxel is used in the study of lung, breast, and ovarian cancers; it may be useful in the research of other cancer types
  • It is suitable for cell culture, biochemistry, and molecular biology applications
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 33069-62-4
Molecular Formula C47H51NO14
Molecular Weight (g/mol) 853.92
MDL Number MFCD00869953
InChI Key RCINICONZNJXQF-VAZQATRQSA-N
Synonym paclitaxel, taxol, taxol a, abraxane, paxene, paxceed, plaxicel, yewtaxan, onxol, ebetaxel
PubChem CID 133640187
IUPAC Name (1S,2S,4S,7R,9S,10S,12R,15S)-4,12-bis(acetyloxy)-1,9-dihydroxy-15-{[(2R,3S)-2-hydroxy-3-phenyl-3-(phenylformamido)propanoyl]oxy}-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0³,¹⁰.0⁴,⁷]heptadec-13-en-2-yl benzoate
SMILES CC(=O)O[C@@H]1C2=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)C3=CC=CC=C3)C3[C@@]4(CO[C@@H]4C[C@H](O)[C@@]3(C)C1=O)OC(C)=O)C2(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)C1=CC=CC=C1)C1=CC=CC=C1

Specifications

Melting Point 213°C (decomposition)
Color White
Quantity 100 mg
Beilstein 1420457
Merck Index 14,6982
Solubility Information Soluble in DMSO (200mg/ml) or ethanol (40mg/ml); Soluble in dimethylsulfoxide,methanol,ethanol,acetonitrile,cremophor and dimehtylsulfamide; Sparingly soluble in aqueous buffer.
Formula Weight 853.91
Percent Purity ≥99.5%
Physical Form Crystalline Solid
Chemical Name or Material Paclitaxel

Safety and Handling

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Product Identifier
  • Paclitaxel
 Signal Word
  • Danger
 Hazard Category
  • LONG-TERM AQUATIC HAZARD Chronic 4
  • Serious eye damage/eye irritation Category 1
  • Reproductive toxicity Category 2
  • Skin corrosion/irritation Category 2
  • Skin sensitiser Category 1
  • Specific target organ toxicity Category 3
 Hazard Statement
  • H315-Causes skin irritation.
  • H317-May cause an allergic skin reaction.
  • H318-Causes serious eye damage.
  • H335-May cause respiratory irritation.
  • H361-Suspected of damaging fertility or the unborn child.
  • H413-May cause long lasting harmful effects to aquatic life.
 Precautionary Statement
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P302+P352-IF ON SKIN: Wash with plenty of water/soap.
  • P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
  • P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P310-Immediately call a POISON CENTER/doctor/.
 Supplemental information
  • MIXTURE LIST-Contain: Paclitaxel
SDS

RUO – Research Use Only

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