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Thermo Scientific Chemicals Paclitaxel, 99+%

Artikelnummer. 10516261 Alle ansehen Thermo Scientific Chemicals Produkte
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Artikelnummer. 10516261 Lieferant Thermo Scientific Chemicals Lieferanten-Nr. 328420010
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Beschreibung

Paclitaxel, also known as Taxol, CAS # 33069-62-4 is a chemotherapeutic drug that acts through stabilizing microtubule assembly and arresting cell cycle progression. | CAS: 33069-62-4 | C47H51NO14 | 853.92 g/mol

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Paclitaxel is a naturally ocurring compound originally isolated from the tree T. brevifolia
  • Paclitaxel binds tubulin and stabilizes microtubule formation, preventing disassembly
  • Paclitaxel is used as a drug to arrest cells at the mitotic checkpoint and block cell cycle progression, thus inducing death of cancer cells

Applications

  • Paclitaxel can be used in preclinical laboratory research on diseases such as cancer, heart disease, inflammatory disorders, and hepatic fibrosis
  • Paclitaxel can be used as a tool in cell biology to study mitotic checkpoint arrest conditions and downstream signaling cascades
TRUSTED_SUSTAINABILITY

Chemische Identifikatoren

CAS 33069-62-4
Molecular Formula C47H51NO14
Molecular Weight (g/mol) 853.92
MDL Number MFCD00869953
InChI Key RCINICONZNJXQF-VAZQATRQSA-N
Synonym paclitaxel, taxol, taxol a, abraxane, paxene, paxceed, plaxicel, yewtaxan, onxol, ebetaxel
PubChem CID 133640187
IUPAC Name (1S,2S,4S,7R,9S,10S,12R,15S)-4,12-bis(acetyloxy)-1,9-dihydroxy-15-{[(2R,3S)-2-hydroxy-3-phenyl-3-(phenylformamido)propanoyl]oxy}-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0³,¹⁰.0⁴,⁷]heptadec-13-en-2-yl benzoate
SMILES CC(=O)O[C@@H]1C2=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)C3=CC=CC=C3)C3[C@@]4(CO[C@@H]4C[C@H](O)[C@@]3(C)C1=O)OC(C)=O)C2(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)C1=CC=CC=C1)C1=CC=CC=C1

Spezifikation

Melting Point 213.0°C to 216.0°C
Color White
Infrared Spectrum Authentic
Assay Percent Range 99% min. (HPLC)
Quantity 1 mg
Merck Index 15, 7081
Solubility Information Solubility in water: sparingly soluble. Other solubilities: soluble in methanol,dmso,acetonitrile
Formula Weight 853.9
Percent Purity 99+%
Physical Form Powder
Chemical Name or Material Paclitaxel, 99+%
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Sicherheit und Handhabung

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Produktidentifikator
  • Paclitaxel
 Signalwort
  • Danger
 Gefahrenkategorie
  • LONG-TERM AQUATIC HAZARD Chronic 4
  • Serious eye damage/eye irritation Category 1
  • Reproductive toxicity Category 2
  • Skin corrosion/irritation Category 2
  • Skin sensitiser Category 1
  • Specific target organ toxicity Category 3
 Gefahrenhinweis
  • H315-Causes skin irritation.
  • H317-May cause an allergic skin reaction.
  • H318-Causes serious eye damage.
  • H335-May cause respiratory irritation.
  • H361-Suspected of damaging fertility or the unborn child.
  • H413-May cause long lasting harmful effects to aquatic life.
 Sicherheitshinweis
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P302+P352-IF ON SKIN: Wash with plenty of water/.
  • P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
  • P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P310-Immediately call a POISON CENTER/doctor/.

RUO – Research Use Only

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