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Novobiocin Sodium Salt, MP Biomedicals™

Product Code. 17660877 Shop All MP Biomedicals Products
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Artikelnummer. 17660877 Lieferant MP Biomedicals Lieferanten-Nr. 0215595701

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Beschreibung

Inhibits DNA synthesis by inhibiting the enzyme Topoisomerase II. Novobiocin Sodium Salt, MP Biomedicals is an antibiotic produced by Streptomyces nieveus. It is active against gram-positive bacteria. It is also a Hsp90 inhibitor 3.

Novobiocin inhibits DNA synthesis by inhibiting bacterial DNA gyrase targeting the GyrB subunit of the enzyme involved in energy transduction. It acts as a competitive inhibitor of the ATPase reaction catalysed by GyrB 2. Uses include:

  • For the production of positively supercoiled plasmid DNA
  • Inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase
  • Inhibitor of retrovirus RNA-dependent DNA-polymerase
  • To study heat shock protein inhibition
TRUSTED_SUSTAINABILITY

Chemische Identifikatoren

CAS 1476-53-5
Molecular Formula C31H35N2NaO11
Molecular Weight (g/mol) 634.61
MDL Number MFCD00066541,MFCD00066541
InChI Key AXOUUAINTJNFRS-UHFFFAOYNA-N
Synonym Albamycin, Cathomycin sodium
PubChem CID 131673945
SMILES [Na+].COC1C(OC(N)=O)C(O)C(OC2=CC=C3C(=O)[C-](NC(=O)C4=CC=C(O)C(CC=C(C)C)=C4)C(=O)OC3=C2C)OC1(C)C

Spezifikation

Physical Form Powder
Absorbance λ max: 307nm
Melting Point 220°C
Extinction Coefficient E1%= 600 (0.1M NAOH)
Potency ∼900μg/mg
Quantity 1 g
Optical Rotation −38.0° (2.5g/100ml ethanol at 24°C for the free acid)
Solubility Information Freely soluble in water (10%, clear, colorless solution)
IUPAC Name sodium 7-{[4-(carbamoyloxy)-3-hydroxy-5-methoxy-6,6-dimethyloxan-2-yl]oxy}-3-[4-hydroxy-3-(3-methylbut-2-en-1-yl)benzamido]-8-methyl-2,4-dioxo-3,4-dihydro-2H-1-benzopyran-3-ide
Formula Weight 634.6

Sicherheit und Handhabung

compliance-icons
Produktidentifikator
  • Novobiocin Sodium Salt
 Signalwort
  • Warning
 Gefahrenkategorie
  • Serious eye damage/eye irritation Category 2
  • Skin sensitiser Category 1
 Gefahrenhinweis
  • H317-May cause an allergic skin reaction.
  • H319-Causes serious eye irritation.
 Sicherheitshinweis
  • P101-If medical advice is needed, have product container or label at hand.
  • P102-Keep out of reach of children.
  • P103-Read label before use.
  • P261-Avoid breathing dust/fume/gas/mist/vapours/spray.
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P333+P313-If skin irritation or rash occurs: Get medical advice/attention.
  • P337+P313-If eye irritation persists: Get medical advice/attention.
  • P501b-Dispose of contents/container in accordance with local/regional/national/international regulations.
 Ergänzende Informationen
  • MIXTURE LIST-Contains : Novobiocin Sodium Salt
Name des Produkts
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