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  6. Nolatrexed dihydrochloride, MedChemExpress

Nolatrexed dihydrochloride, MedChemExpress

Product Code. 16470547
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Product Code. 16470547

Brand: Medchem Express HY108474

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Description

MedChemExpress Nolatrexed dihydrochloride (AG 337) is a non-competitive lipophilic inhibitor of thymidylate synthase, interacts at the folate cofactor binding site of the enzyme, with a Ki of 11 nM for human thymidylate synthase. Nolatrexed dihydrochloride (AG 337) induces cell cycle arrest in S phase of cancer cells. Anti-cancer activity.

Nolatrexed dihydrochloride (AG 337) is a non-competitive lipophilic inhibitor of thymidylate synthase, interacts at the folate cofactor binding site of the enzyme, with a Ki of 11 nM for human thymidylate synthase. Nolatrexed dihydrochloride (AG 337) induces cell cycle arrest in S phase of cancer cells. Anti-cancer activity.

Specifications

Chemical Name or Material Nolatrexed dihydrochloride
Physical Form Solid
CAS 152946-68-4
Color Yellow
Quantity 50 mg
Purity Grade Notes Research
Molecular Formula C14H14Cl2N4OS
For Use With (Application) Cancer-programmed cell death
Synonym AG 337 Thymitaq
Solubility Information H2O : 50 mg/mL (139.95 mM; Need ultrasonic) ∣DMSO : 41.67 mg/mL (116.64 mM; Need ultrasonic)
SMILES [H]Cl.O=C1N=C(N)NC2=C1C(SC3=CC=NC=C3)=C(C)C=C2.[H]Cl
Molecular Weight (g/mol) 357.26
Formula Weight 357.26
Percent Purity 98.54%
Grade Research
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Research purposes only

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