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STEMCELL Technologies Nilotinib

Product Code. 17130202
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Product Code. 17130202 Supplier STEMCELL Technologies Supplier No. 73302

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Description

Tyrosine kinase inhibitor; Inhibits BCR/ABL and ABL

  • Nilotinib is a second-generation inhibitor of the oncogenic tyrosine kinase BCR-ABL with IC50 values of 19, 140, and 9,200 nM for wild-type, E255K, and T315I mutant forms of BCR-ABL, respectively (Kitagawa et al.; Verstovsek et al.; O'Hare)
  • It binds to the ATP-binding pocket of ABL, with higher affinity than imatinib (Manley et al. 2006; Verstovsek et al.) It also has activity below 1 μM against discoidin domain receptors (DDR) -1 and -2, platelet-derived growth factor receptors (PDGFR) –α and -β, stem cell factor receptor (KIT), and colony-stimulating factor 1 receptor (CSF-1R; Manley et al. 2010)

Specifications

CAS 641571-10-0
Synonym AMN107; Tasigna
Quantity 10 mg
Molecular Formula C28H22F3N7O
Purity ≥95%
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