missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Chemicals
  4. Organic compounds
  5. Benzenoids
  6. Benzene and substituted derivatives
  7. Benzamides
  8. 15467689

Methotrexate disodium salt, 98.5%

Product Code. 15467689
Change view
Click to view available options
Quantity:
250 mg
Unit Size:
250mg
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Product Code. Quantity Unit Size
15467689 250 mg 250mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
This item is not returnable. View return policy
Product Code. 15467689 Supplier Thermo Scientific Alfa Aesar Supplier No. J66364.MD
 Restricted Item
In Stock
Add to basket

missing translation for 'validMainframeMsg'

This item is not returnable. View return policy

Description

Methotrexate disodium salt, CAS # 7413-34-5, is the sodium salt of methotrexate that shows antineoplastic, antirheumatic, dermatologic, and immunosuppressive activities. | CAS: 7413-34-5 | C20H20N8Na2O5 | 498.411 g/mol

Inhibits the metabolism of folic acid

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Methotrexate disodium salt is an organic sodium salt derived from methotrexate with antineoplastic, antirheumatic, dermatologic, and immunosuppressive activities

• It acts as an enzyme inhibitor of dihydrofolate reductase

• It binds to and inhibits purine nucleotide and thymidylate synthesis, leading to the inhibition of DNA and RNA synthesis. Because of this mechanism of action, the methotrexate disodium salt is defined as a nucleic acid synthesis inhibitor

Application

• Methotrexate disodium salt is a folic acid antagonist with the ability to inhibit folic acid metabolism

• In vitro studies demonstrated that methotrexate disodium salt has potent activity against pyrimethamine-resistant Plasmodium vivax malaria parasites

• This compound has been used in chimeric polymersomes in order to investigate its effect in lung tumor xenografts in mice

TRUSTED_SUSTAINABILITY

Specifications

CAS 7413-34-5
Color Yellow
Boiling Point 823°C
Molecular Formula C20H20N8Na2O5
MDL Number MFCD00274560
Quantity 250 mg
UN Number UN2811
Sensitivity Hygroscopic
Synonym methotrexate disodium salt, sodium methotrexate, ledertrexate, methotrexate sodium, mtx disodium, methotrexate disodium, unii-3ig1e710zn, trexall, mexate, methotrexate lpf
Solubility Information Soluble in water
InChI Key DASQOOZCTWOQPA-GXKRWWSZSA-L
SMILES CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)[O-])C(=O)[O-].[Na+].[Na+]
IUPAC Name disodium;(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioate
Molecular Weight (g/mol) 498.411
PubChem CID 11329481
ChEBI CHEBI:50679
Formula Weight 498.4
Percent Purity 98.5%
Physical Form Powder
Chemical Name or Material Methotrexate disodium salt
Show More Show Less

Safety and Handling

compliance-icons compliance-icons
Product Identifier
  • Methotrexate disodium salt
 Signal Word
  • Danger
 Hazard Category
  • Acute toxicity Category 3
  • Serious eye damage/eye irritation Category 2
  • Germ cell mutagenicity Category 1B
  • Skin corrosion/irritation Category 2
  • Specific target organ toxicity Category 3
 Hazard Statement
  • H301-Toxic if swallowed.
  • H315-Causes skin irritation.
  • H319-Causes serious eye irritation.
  • H335-May cause respiratory irritation.
  • H340-May cause genetic defects.
  • H360FD-May damage fertility. May damage the unborn child.
 Precautionary Statement
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
  • P302+P352-IF ON SKIN: Wash with plenty of water/soap.
  • P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
  • P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P312-Call a POISON CENTER/doctor/if you feel unwell.
 Supplemental information
  • MIXTURE LIST-Contain: Disodium N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamate
SDS

RUO – Research Use Only

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.