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Thermo Scientific™ MethElute™ Reagent (TMPAH)
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For accurate, sensitive on-column methylation use Thermo Scientific™ MethElute™ Reagent (TMPAH).
For accurate, sensitive, on-column methylation and detection by GC analysis use Thermo Scientific™ MethElute™ Reagent (TMPAH). It is ideally suited for the quantitative methylation and detection of barbiturates, sedatives, xanthine bases, phenolic alkaloids, and phenytoin, giving a single quantitative peak for each substance. When the reagent is heated with drug-containing extracts, serum, or urine the drugs containing reactive amino, hydroxyl, and carboxyl functions will be methylated at the reactive sites.
Accuracy comparable or better than the UV/TLC method (GC is superior to UV/TLC when phenobarbitol and phenytoin present)
High precision, with coefficient of variation of 5% or less
High sensitivity; barbiturates deteced down to 0.2 mg/dL
Specifications
Specifications
| For Use With | GC |
| Hazards | Flammable, Toxic |
| Storage | Room Temperature |
| Standard Components | Trimethylanilinium hydroxide in Methanol |
| Standard Concentration | 0.2 M |
| Item Description | 12 x 1 mL |
| Quantity | 12 x 1 mL |
Safety and Handling
- MethElute Reagent (TMPAH)
- Danger
- Acute toxicity Category 1
- Acute toxicity Category 2
- Acute toxicity Category 3
- Serious eye damage/eye irritation Category 1
- Flammable liquid Category 2
- Specific target organ toxicity after single exposure Category 1
- H225-Highly flammable liquid and vapour.
- H300-Fatal if swallowed.
- H310-Fatal in contact with skin.
- H318-Causes serious eye damage.
- H331-Toxic if inhaled.
- H370-Causes damage to organs.
- P210-Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
- P261-Avoid breathing dust/fume/gas/mist/vapours/spray.
- P262-Do not get in eyes, on skin, or on clothing.
- P264-Wash hands thoroughly after handling.
- P280-Wear protective gloves/protective clothing/eye protection/face protection.
- P301+P310-IF SWALLOWED: Immediately call a POISON CENTER/doctor /
- P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
- P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P310-Immediately call a POISON CENTER/doctor/.
- P370+P378-In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish.
- P403+P233-Store in a well-ventilated place. Keep container tightly closed.
- P403+P235-Store in a well-ventilated place. Keep cool.
- P501b-Dispose of contents/container in accordance with local/regional/national/international regulations.
- MIXTURE LIST-Contains : methanol
For Research Use Only. Not for use in diagnostic procedures.
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