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M3258, MedChemExpress

Product Code. 16484528
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16417247 5 mg 5mg
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Product Code. 16484528 Supplier Medchem Express Supplier No. HY111790

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Description

MedChemExpress M3258 is an orally bioavailable, potent, reversible and highly selective immunoproteasome subunit LMP7 (β5i) inhibitor.

M3258 exerts high biochemical (IC50=3.6 nM) and cellular (IC50=3.4 nM) potency against the LMP7 subunit. M3258 shows strong antitumor efficacy in multiple myeloma xenograft models. M3258 leads to a significant and prolonged suppression of tumor LMP7 activity and ubiquitinated protein turnover and the induction of apoptosis in multiple myeloma cells.

Specifications

Chemical Name or Material M3258
CAS 2285330-15-4
Color White
Purity Grade Notes Research
Molecular Formula C17H20BNO5
Quantity 10 mg
Solubility Information DMSO : 250 mg/mL (759.51 mM; Need ultrasonic)
SMILES O=C(N[C@@H](CC1=COC2=C1C=CC=C2)B(O)O)[C@H]3[C@@H]4CC[C@@H](O4)C3
Molecular Weight (g/mol) 329.16
Formula Weight 329.16
Percent Purity 98.0%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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