Invitrogen™ LSR Polyclonal Antibody

Lipolysis-stimulated lipoprotein receptor (LSR), encoded by the LSR gene, is a crucial component in lipid metabolism, particularly involved in the endocytosis of triglyceride-rich lipoproteins. It is typically expressed in liver and adipose tissues, playing a pivotal role in maintaining lipid and glucose homeostasis. LSR binds to lipoproteins in the presence of free fatty acids, facilitating the uptake and clearance of lipids from the bloodstream, which is significant in preventing atherosclerosis and other lipid-related disorders. The protein functions as a multi-subunit complex, which includes two isoforms, LSRα and LSRβ, each contributing to lipoprotein metabolism. Research has highlighted its involvement in metabolic processes and its potential impacts on obesity and insulin resistance. LSR has also been studied in the context of hepatic lipid accumulation, where its downregulation is associated with increased lipid deposition in the liver, suggesting its importance in preventing non-alcoholic fatty liver disease (NAFLD). Due to its central role in lipid metabolism, LSR has emerged as a potential therapeutic target for metabolic diseases and cardiovascular conditions.