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Description
PAX-5 is a B-cell-specific activator protein (BSAP). In the early stages of B cell developmemt, PAX-5 influences the expression of several B-cell-specific genes, such as CD19 and CD20. PAX-5 is expressed primarily in pro-, pre-, and mature B cells, but not in plasma cells. PAX-5 is expressed in most B-cell malignancies (pre-B and mature B cell lymphomas/leukemias). Over 90% of cases are positive for PAX-5 in Hodgkin's lymphoma, lymphoplasmacytic lymphoma, Merkel cell and small cell carcinoma. T-cell lymphomas, myeloma/plasmacytoma and carcinoid tumors are negative for PAX-5.
Host Species: Rabbit
Clone: SP34
Isotype: IgG
Species Reactivity: Human. Others not tested.
Immunogen: Synthetic peptide derived from the C-terminus of human PAX-5 protein
Molecular Weight: 50kDa
Positive Control: Tonsil
Cellular Localization: Nuclear
Recommended for:
- Immunohistochemistry (Formalin/paraffin)
Specifications
Specifications
| Antigen | PAX-5 |
| Applications | Immunohistochemistry (Paraffin) |
| Classification | Monoclonal |
| Clone | SP34 |
| Conjugate | Unconjugated |
| Host Species | Rabbit |
| Immunogen | Synthetic peptide derived from the C-terminus of human Pax-5 protein |
| Quantity | 12 mL |
| Regulatory Status | IVD |
| Research Discipline | Cancer and Tumor Biology |
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