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Imatinib, MedChemExpress

Product Code. 16481519
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Product Code. 16481519 Supplier Medchem Express Supplier No. HY15463

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Description

MedChemExpress Imatinib (STI571) is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity. Imatinib (STI571) works by binding close to the ATP binding site, locking it in a closed or self-inhibited conformation, therefore inhibiting the enzyme activity of the protein semicompetitively. Imatinib also is an inhibitor of SARS-CoV and MERS-CoV.

Imatinib (STI571) is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, v-Abl, PDGFR and c-kit kinase activity. Imatinib (STI571) works by binding close to the ATP binding site, locking it in a closed or self-inhibited conformation, therefore inhibiting the enzyme activity of the protein semicompetitively. Imatinib also is an inhibitor of SARS-CoV and MERS-CoV.

Specifications

Chemical Name or Material Imatinib
Physical Form Solid
CAS 152459-95-5
Color Light Yellow
Quantity 1 g
Purity Grade Notes Research
Molecular Formula C29H31N7O
For Use With (Application) Cancer-Kinase/protease
Synonym STI571 CGP-57148B
Solubility Information DMSO : 12.5 mg/mL (25.32 mM; Need ultrasonic) ∣H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
SMILES CN(CC1)CCN1CC2=CC=C(C(NC3=CC=C(C)C(NC4=NC(C5=CC=CN=C5)=CC=N4)=C3)=O)C=C2
Molecular Weight (g/mol) 493.6
Formula Weight 493.6
Percent Purity 99.4%
Grade Research
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Research purposes only

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