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IDH-305, MedChemExpress

Product Code. 16484956
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Product Code. 16484956 Supplier Medchem Express Supplier No. HY104036

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Description

MedChemExpress IDH-305 is an orally available, mutant-selective and brain-penetrant IDH1 inhibitor that targets IDH1 (R132) mutation. IDH-305 exhibits greater than 200 fold selectivity for mutant IDH1 isoforms vs. WT (IC50= 27 nM (IDH1R132H), 28 nM (IDH1R132C), 6.14 μM (IDH1WT)).

IDH-305 is an orally available, mutant-selective and brain-penetrant IDH1 inhibitor that targets IDH1 (R132) mutation. IDH-305 exhibits greater than 200 fold selectivity for mutant IDH1 isoforms vs. WT (IC50= 27 nM (IDH1R132H), 28 nM (IDH1R132C), 6.14 μM (IDH1WT)).

Specifications

Chemical Name or Material IDH-305
CAS 1628805-46-8
Color Off-White
Purity Grade Notes Research
Molecular Formula C23H22F4N6O2
Quantity 100 mg
Solubility Information DMSO : ≥ 150 mg/mL (305.84 mM)
SMILES O=C1OC[C@H]([C@@H](F)C)N1C2=NC(N[C@H](C3=CC(C)=C(C4=CC(C(F)(F)F)=NC=C4)C=N3)C)=NC=C2
Molecular Weight (g/mol) 490.45
Formula Weight 490.45
Percent Purity 98.0%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-programmed cell death
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Research purposes only

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