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  5. Tocris Bioscience™ ICI 182,780

Tocris Bioscience™ ICI 182,780
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Product Code. 18742564
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Quantity:
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50 mg
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1mg
50mg
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Product Code. 18742564

Brand: Tocris Bioscience™ 1047/1

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Description

Estrogen receptor antagonist

ICI 182,780 is a high affinity estrogen receptor antagonist (IC50 = 0.29 nM), devoid of any partial agonism both in vitro and in vivo. ICI 182,780 is a high affinity agonist at the membrane estrogen receptor GPER. ICI 182,780 inhibits MCF-7 human breast cancer cell growth in vitro and shows antitumor activity in mice models. ICI 182,780 penetrates the blood-brain-barrier and has neuronal functional effects in vivo.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 129453-61-8
Molecular Formula C32H47F5O3S

Specifications

Quantity 1 mg
Formula Weight 606.77
Purity >99%
Molecular Weight (g/mol) 606.777
Chemical Name or Material ICI 182, 780
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