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Gibco™ Human/Mouse/Rat BDNF Recombinant Protein, PeproTech®

Artikelnummer. 17834733
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17834733 10 μg 10µg
17874463 100 μg 100µg
17824183 1 mg 1mg
17894313 250 μg 250µg
17854143 2 μg 2µg
17854253 500 μg 500µg
17874523 50 μg 50µg
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Artikelnummer. 17834733 Lieferant Gibco™ Lieferanten-Nr. 4500210UG
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Beschreibung

Recombinant Protein

Recombinant Human/Murine/Rat BDNF is a 27.0 kDa homodimer of two 120 amino acid subunits linked by strong non-covalent interactions. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

BDNF (Brain-Derived Neurotrophic Factor) is a member of the neurotrophin family. BDNF is synthesized as pre-proBDNF, followed by cleavage to proBDNF. Although further processing generates the mature, 14 kDa protein, pro-BDNF is biologically active and is secreted in synaptic vesicles along with the mature form. BDNF is widely expressed in the central nervous system and acts in an autocrine and paracrine manner on several classes of neurons. Signaling occurs mainly through the tyrosine kinase receptor TrkB, although binding to the lower-affinity receptor, p75-NTR, has also been demonstrated. BDNF promotes neuronal survival and differentiation and has been shown to play a critical role in memory formation and synaptic regulation. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of BDNF is reduced in both Alzheimer's and Huntington disease patients, and may also play a role in the regulation of stress response and in the biology of mood disorders.
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Spezifikation

Accession Number P21237, P23363, P23560
For Use With (Application) Binding Assay, Bioactivity, Control, ELISA Standard, Western Blot Control
Formulation Protein with no preservative
Gene ID (Entrez) 12064, 24225, 627
Molecular Weight (g/mol) 27 kDa
Name Human/Mouse/Rat BDNF
Purification Method Purified
Quantity 10 μg
Source E. coli
Storage Requirements -20°C
Regulatory Status RUO
Endotoxin Concentration <1 EU/μg
Gene Alias abrineurin; ANON2; anorexia BDNF; Bdnf; BDNF precursor form; bdnf protein; brain derived neurothrophic factor; brain derived neurotrophic factor; brain-derived neurotrophic factor; BULN2; H-BDNF; neurotrophin; ProBDNF
Common Name BDNF
Gene Symbol BDNF
Biological Activity Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA.
Product Type Protein
Conjugate Unconjugated
Recombinant Recombinant
Sequence MHSDPARRGE LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN PMGYTKEGCR GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR
Content And Storage -20°C
Activity Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA.
Expression System E. coli
Form Lyophilized
Purity or Quality Grade ≥ 98% by SDS-PAGE gel and HPLC analyses.
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