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  5. Tocris Bioscience™ HTH 01-015

Tocris Bioscience™ HTH 01-015
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Product Code. p-7110850
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18778328 10 mg 10mg
18740268 50 mg 50mg
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Product Code. 18778328 Supplier Tocris Bioscience™ Supplier No. 5622/10

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Description

Potent and selective NUAK1 inhibitor

HTH 01-015 is a potent and selective NUAK1 inhibitor (IC50 = 100 nM). Exhibits no significant inhibition against a panel of 139 kinases, including ten AMPK family members. Inhibits NUAK1-mediated MYPT1 phosphorylation. Also inhibits cell proliferation in U2OS cells in vitro, to a similar extent as NUAK1 knockdown models.
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Specifications

Chemical Name or Material 5,13-Dihydro-4,5,13-trimethyl-2-[[1-(4-piperidinyl)-1H-pyrazol-4-yl]amino]-6H-naphtho[2,3-e]pyrimido[5,4-b][1,4]diazepin-6-one
CAS 1613724-42-7
Quantity 10 mg
Target Other Kinase Inhibitors
Molecular Formula C26H28N8O
Formula Weight 468.55
Purity >98%
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