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AcroBiosystems GMP Human IL-10 Protein

Product Code. 31451649
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31451649 1 mg
31451966 50 μg
31451673 10 mg
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Product Code. 31451649 Supplier AcroBiosystems Supplier No. GMPL10H251mg

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Description

Recombinant Protein

The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. [provided by RefSeq, May 2020]

Specifications

Accession Number Uniprot
Characterization IL-10 Structure This protein carries no tag. The protein has a calculated MW of 18.6 kDa. The protein migrates as 17 kDa±3 kDa when calibrated against under reducing (R) condition (SDS-PAGE).
Format Powder-GMP
Formulation Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4 with protectants. Contact us for customized product form or formulation.
Quality Control Testing <0.5 ng/μg of protein tested by ELISA.∣<0.02 ng/μg of protein tested by qPCR.∣Less than 10 EU/mg, tested by the LAL method in compliance with USP 85 and Ph. Eur. 2.6.14.∣Sterility testing was performed using the membrane filtration method in compliance with USP &CM and Ph. Eur. 2.6.1.∣Negative
Quantity 1 mg
Source GMP Human IL-10 Protein (GMP-L10H25) is expressed from human 293 cells (HEK293). It contains AA Ser 19 - Asn 178 (Accession # ). Predicted N-terminus: Ser 19 Request for sequence
Biological Activity GMP Human IL-10 Protein (Cat. No. GMP-L10H25) inhibits the secretion IL-6 by RAW264.7 cells. The specific activity of GMP Human IL-10 Protein is >1.00 x 10^7 IU/mg, which is calibrated against WHO Reference Reagent Interleukin-10 (Human, rDNA derived) (NIBSC code: 93/722) (QC tested).∣The activity of GMP Human IL-10 (Cat. No. GMP-L10H25) was higher than other competing products.∣The Cell based assay shows that GMP Human IL-10 (Cat. No. GMP-L10H25) is stable at 37 °C for 24 hours.∣The Cell based assay shows that GMP Human IL-10 Protein (Cat. No. GMP-L10H25) is stable at 4°C for 180 days.∣The Cell based assay shows that GMP Human IL-10 (Cat. No. GMP-L10H25) is stable after freezing and thawing 3 times.∣The Cell based assay shows batch-to-batch consistency between Acro's GMP and PG IL-10.
Species Human
Sterility Sterile
Content And Storage -20°C to -70°C for 5 years in lyophilized state; -70°C for 12 months under sterile conditions after reconstitution. Upon receipt, store it immediately at -20°C or lower for long term storage.
Endotoxin Level Less than 10 EU/mg, tested by the LAL method in compliance with USP 85 and Ph. Eur. 2.6.14.
Shipping Condition This product is supplied and shipped with blue ice, please inquire the shipping cost.
Specific Activity The activity of GMP Human IL-10 (Cat. No. GMP-L10H25) was higher than other competing products.
Purity or Quality Grade 0.95
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