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AcroBiosystems GMP Human Activin A / INHBA Protein

Product Code. 31452583
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31452583 1 mg
31452264 50 μg
31451674 10 mg
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Product Code. 31452583 Supplier AcroBiosystems Supplier No. GMPACAH371mg

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Description

Recombinant Protein

Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Activin enhances FSH biosynthesis and secretion, and participates in the regulation of the menstrual cycle. Many other functions have been found to be exerted by activin, including roles in cell proliferation, differentiation, apoptosis, metabolism, homeostasis, immune response, wound repair, and endocrine function. Conversely inhibin down regulates FSH synthesis and inhibits FSH secretion.Activins are nonglycosylated homodimers or heterodimers of various β subunits (βA, βB, βC, and βE in mammals), while Inhibins are heterodimers of a unique α subunit and one of the β subunits. Activin A is a widely expressed homodimer of two βA chains. The βA subunit can also heterodimerize with a βB or βC subunit to form Activin AB and Activin AC, respectively. The 14 kDa mature human βA chain shares 100% amino acid sequence identity with bovine, feline, mouse, porcine, and rat βA.

Specifications

Accession Number Uniprot
Characterization Activin A Structure This protein carries no tag. The protein has a calculated MW of 13.0 kDa. The protein migrates as 13 kDa±3 kDa when calibrated against under reducing (R) condition (SDS-PAGE) due to glycosylation.
Format Powder-GMP
Formulation Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4 with protectants. Contact us for customized product form or formulation.
Quality Control Testing <0.5 ng/μg of protein tested by ELISA.∣<0.02 ng/μg of protein tested by qPCR.∣Less than 10 EU/mg, tested by the LAL method in compliance with USP 85 and Ph. Eur. 2.6.14.∣Sterility testing was performed using the membrane filtration method in compliance with USP &CM and Ph. Eur. 2.6.1.∣Negative
Quantity 1 mg
Source GMP Human Activin A Protein (GMP-ACAH37) is expressed from CHO cells. It contains AA Gly 311 - Ser 426 (Accession # ). Predicted N-terminus: Gly 311 Request for sequence
Biological Activity GMP Human Activin A Protein (Cat. No. GMP-ACAH37) stimulates Human Activin RII (Luc) HEK293 Reporter Cell. The specific activity of GMP Human Activin A Protein is >5.00x10^2 IU/mg, which is calibrated against WHO Reference Reagent Activin A (Human, Recombinant) (NIBSC code: 91/626) (QC tested).∣The activity of GMP Human Activin A Protein (Cat. No. GMP-ACAH37) was higher than other competing products.∣GMP Human Activin A Protein (Cat. No. GMP-ACAH37) and Human FGF-7 Protein, premium grade (Cat. No. FG7-H5213) coating with GMP Human Laminin 521 Protein (Cat. No. GMP-LA5H24) could induce the PP2 (Pancreatic progenitor cells) differentiation, with high expression of marker genes (PDX1 and SOX9) in immunofluorescence.∣GMP Human Activin A Protein (Cat. No. GMP-ACAH37) and Human FGF-7 Protein, premium grade (Cat. No. FG7-H5213) coating with GMP Human Laminin 521 Protein (Cat. No. GMP-LA5H24) could induce the PP2 (Pancreatic progenitor cells) differentiation, with high expression of marker genes (PDX1, SOX9 and NKX6.1) in FACS.∣GMP Human Activin A Protein (Cat. No. GMP-ACAH37) could effectively induce the endoderm differentiation by FOXA2 and SOX17 expression in immunofluorescence and FACS.∣The Cell based assay shows that GMP Human Activin A Protein (Cat. No. GMP-ACAH37) is stable at 37°C for 7 hours.∣The Cell based assay shows that GMP Human Activin A Protein (Cat. No. GMP-ACAH37) is stable at 4°C for 180 days.∣The Cell based assay shows that GMP Human Activin A Protein (Cat. No. GMP-ACAH37) is stable after freezing and thawing 3 times.∣The Cell based assay shows batch-to-batch consistency between Acro's GMP and PG Activin A.
Species Human
Sterility Sterile
Content And Storage -20°C to -70°C for 5 years in lyophilized state; -70°C for 12 months under sterile conditions after reconstitution. Upon receipt, store it immediately at -20°C or lower for long term storage.
Endotoxin Level Less than 10 EU/mg, tested by the LAL method in compliance with USP 85 and Ph. Eur. 2.6.14.
Shipping Condition This product is supplied and shipped with blue ice, please inquire the shipping cost.
Specific Activity The activity of GMP Human Activin A Protein (Cat. No. GMP-ACAH37) was higher than other competing products.
Purity or Quality Grade 0.95
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