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Tocris Bioscience™ Givinostat hydrochloride
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Product Code. 18757946
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25 mg
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18757946 25 mg 25mg
18759466 5 mg 5mg
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Product Code. 18757946 Supplier Tocris Bioscience™ Supplier No. 6249/25

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458.20 EUR valid until 2026-03-31
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Description

Histone deacetylase inhibitor

Givinostat hydrochloride is a histone deacetylase (HDAC) inhibitor (IC50 = 7.5 to 16 nM). At low concentrations reduces release of pro-inflammatory cytokines, including TNFα, INFγ, IL-1α and IL-1β, from LPS stimulated PBMCs in vitro. Exhibits anti-inflammatory effects in vivo. Improves functional recovery and attenuates tissue damage in a mouse model of traumatic brain injury.
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Specifications

Chemical Name or Material [6-[(Diethylamino)methyl]-2-naphthalenyl]methyl-N-[4-[(hydroxyamino)carbonyl]phenyl]carbamate hydrochloride
CAS 199657-29-9
Assay Percent Range >98%
Quantity 25 mg
Molecular Formula C24H27N3O4.HCl
Formula Weight Observed MW: 457.95
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