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Tocris Bioscience™ FK 506
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Product Code. 18756286
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18756286 10mg
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Product Code. 18756286 Supplier Tocris Bioscience™ Supplier No. 3631/10

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Description

Potent calcineurin inhibitor; immunosuppressant

FK 506 is a potent calcineurin (protein phosphatase 2B) inhibitor that requires FK 506-binding protein 12 (FKBP12) for activity (IC50 = 3 nM). Inhibits secretion of IL-1, IL-2 (IC50 = 1 nM), IL-3, IL-4, IL-6 (IC50 = 35 nM), GM-CSF, TNFα (IC50 = 10 nM), IFNγ and Myc from activated T cells in vitro. Exhibits potent immunosuppressive, neuroprotective and anticonvulsant activity in vivo. Identified as targeting human host cell proteins that interact with SARS-CoV-2.

Analog also available.

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Specifications

Quantity 10 mg
Product Type FK 506
Purity >99%
Molecular Weight (g/mol) 804.02
Inhibitors FK 506

For Research Use Only

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