missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Chemicals
  4. Organic compounds
  5. Organic acids and derivatives
  6. Organic sulfonic acids and derivatives
  7. 15415739

Fasudil, 98+%

Product Code. 15415739
Change view
Click to view available options
Quantity:
10 mg
Unit Size:
10mg
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Product Code. Quantity Unit Size
15415739 10 mg 10mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
This item is not returnable. View return policy
Product Code. 15415739 Supplier Thermo Scientific Alfa Aesar Supplier No. J63525.MA
 Restricted Item
Estimated Shipment: 12-10-2026
Add to basket

missing translation for 'validMainframeMsg'

This item is not returnable. View return policy

Description

CAS: 103745-39-7 | C14H17N3O2S | 291.369 g/mol

HA-1077 dihydrochloride has been shown to be a vasodilating agent as well as a potent inhibitor of Rock-2 (Rho-associated Kinase II), cGKI (cGMP-dependent protein kinase), PKA (cAMP-dependent protein kinase), MYLK, and CaMKII. Rho kinase signaling pathways are thought to cause invasion, migration, and proliferation of certain cells. Studies have shown this compound can also inhibit myosin light chain kinase in vitro and suppress cell rounding by myosin light chain phosphorylation. Mechanistic experiments report that HA-1077 inhibits vascular smooth muscle contraction by acting as a calcium channel protein inhibitor. HA-1077 dihydrochloride is an inhibitor of MSK1, PKC, PRK2 and Rsk-2.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
HA-1077 dihydrochloride has been shown to be a vasodilating agent as well as a potent inhibitor of Rock-2 (Rho-associated Kinase II), cGKI (cGMP-dependent protein kinase), PKA (cAMP-dependent protein kinase), MYLK, and CaMKII. Rho kinase signaling pathways are thought to cause invasion, migration, and proliferation of certain cells. Studies have shown this compound can also inhibit myosin light chain kinase in vitro and suppress cell rounding by myosin light chain phosphorylation. Mechanistic experiments report that HA-1077 inhibits vascular smooth muscle contraction by acting as a calcium channel protein inhibitor. HA-1077 dihydrochloride is an inhibitor of MSK1, PKC, PRK2 and Rsk-2.

Solubility
Soluble in water or DMSO

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from oxidizing agents.
TRUSTED_SUSTAINABILITY

Specifications

CAS 103745-39-7
Color White
Molecular Formula C14H17N3O2S
MDL Number MFCD00866182
Quantity 10 mg
Merck Index 14,3942
Synonym fasudil, fasudil inn, 5-1,4-diazepane-1-sulfonyl isoquinoline, fasudilum inn-latin, 1-5-isoquinolinesulfonyl homopiperazine, unii-q0ch43pgxs, 1h-1,4-diazepine, hexahydro-1-5-isoquinolinylsulfonyl, 5-1,4-diazepan-1-ylsulfonyl isoquinoline, 5-isoquinolinesulfonyl homopiperazine, q0ch43pgxs
Solubility Information Soluble in water or DMSO
InChI Key NGOGFTYYXHNFQH-UHFFFAOYSA-N
SMILES C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3
IUPAC Name 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline
Molecular Weight (g/mol) 291.369
PubChem CID 3547
Formula Weight 327.83
Percent Purity ≥98%
Physical Form Crystalline Powder
Chemical Name or Material Fasudil
Show More Show Less

RUO – Research Use Only

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.