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Entacapone, MedChemExpress

Product Code. 16486018
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Product Code. 16486018 Supplier Medchem Express Supplier No. HY14280

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Description

MedChemExpress Entacapone is a potent, reversible, peripherally acting and orally active catechol-O-methyltransferase (COMT) inhibitor.

Entacapone inhibits COMT from rat brain, erythrocytes and liver with IC50 values of 10 nM, 20 nM, and 160 nM, respectively. Entacapone is selective for COMT over other catecholamine metabolizing enzymes, including MAO-A, MAO-B, phenolsulphotransferase M (PST-M) and PST-P (IC50s>50 μM). Entacapone can be used for the research of Parkinson's disease. Entacapone serves as a inhibitor of FTO demethylation with an IC50 of 3.5 μM, can be used for the research of metabolic disorders.

Specifications

Chemical Name or Material Entacapone
CAS 130929-57-6
Color Yellow
Purity Grade Notes Research
Molecular Formula C14H15N3O5
Quantity 10 mg
Solubility Information DMSO : 33.33 mg/mL (109.17 mM; Need ultrasonic) ∣H2O : 2 mg/mL (6.55 mM; ultrasonic and adjust pH to 10 with NaOH)
SMILES O=C(N(CC)CC)/C(C#N)=C/C1=CC([N+]([O-])=O)=C(O)C(O)=C1
Molecular Weight (g/mol) 305.29
Formula Weight 305.29
Percent Purity 98.79%
Grade Research
Physical Form Powder
For Use With (Application) Neuroscience-Neurodegeneration
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Research purposes only

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