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Embelin, MedChemExpress

Product Code. 16487358
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Product Code. 16487358 Supplier Medchem Express Supplier No. HY17473

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Description

MedChemExpress Embelin (Embelic acid), a potent, nonpeptidic XIAP inhibitor (IC50=4.1 μM), inhibits cell growth, induces apoptosis, and activates caspase-9 in prostate cancer cells with high levels of XIAP. Embelin blocks NF-kappaB signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products. Embelin also induces autophagic and apoptotic cell death in human oral squamous cell carcinoma cells.

Embelin (Embelic acid), a potent, nonpeptidic XIAP inhibitor (IC50=4.1 μM), inhibits cell growth, induces apoptosis, and activates caspase-9 in prostate cancer cells with high levels of XIAP. Embelin blocks NF-kappaB signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products. Embelin also induces autophagic and apoptotic cell death in human oral squamous cell carcinoma cells.

Specifications

Chemical Name or Material Embelin
Physical Form Solid
CAS 550-24-3
Color Orange
Quantity 10 mg
Purity Grade Notes Research
Molecular Formula C17H26O4
For Use With (Application) Cancer-programmed cell death
Synonym Embelic acid Emberine NSC 91874
Solubility Information DMSO : ≥ 50 mg/mL (169.84 mM)
SMILES O=C1C(O)=C(CCCCCCCCCCC)C(C(O)=C1)=O
Molecular Weight (g/mol) 294.39
Formula Weight 294.39
Percent Purity 98.19%
Grade Research
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