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  6. Dolutegravir sodium, MedChemExpress

Dolutegravir sodium, MedChemExpress

Product Code. 16465578
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Product Code. 16465578 Supplier Medchem Express Supplier No. HY13238A

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Description

MedChemExpress Dolutegravir sodium (S/GSK1349572 sodium) is a highly potent and orally bioavailable HIV integrase strand transfer inhibitor with an IC50 of 2.7 nM for HIV-1 integrase-catalyzed strand transfer.

Dolutegravir sodium (S/GSK1349572 sodium) inhibits HIV-1 viral replication with an IC50 of 0.51 nM in peripheral blood mononuclear cells. Dolutegravir sodium (S/GSK1349572 sodium) retains a high potency against the HIV-1 Y143R, N155H, and G140S/Q148H mutants (EC50=3.6-5.8 nM).

Specifications

Chemical Name or Material Dolutegravir sodium
Physical Form Solid
CAS 1051375-19-9
Color Light Yellow
Quantity 10 mg
Purity Grade Notes Research
Molecular Formula C20H18F2N3NaO5
For Use With (Application) COVID-19-anti-virus
Synonym S/GSK1349572 sodium
Solubility Information DMSO : ≥ 4.5 mg/mL (10.20 mM) ∣H2O : < 0.1 mg/mL (insoluble)
SMILES O=C(C1=CN(C2=C(O[Na])C1=O)C[C@]3([H])OCC[C@@H](C)N3C2=O)NCC4=CC=C(F)C=C4F
Molecular Weight (g/mol) 441.36
Formula Weight 441.36
Percent Purity 99.88%
Grade Research
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Research purposes only

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