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  6. D-α-Hydroxyglutaric acid disodium, MedChemExpress

D-α-Hydroxyglutaric acid disodium, MedChemExpress

Product Code. 16472606
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Product Code. 16472606 Supplier Medchem Express Supplier No. HY100542

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Description

MedChemExpress D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria.

D-α-Hydroxyglutaric acid disodium is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a Ki of 10.87 mM. D-α-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR signaling.

Specifications

Chemical Name or Material D-α-Hydroxyglutaric acid disodium
Physical Form Powder
CAS 103404-90-6
Color Off-White
Quantity 25 mg
Purity Grade Notes Research
Molecular Formula C5H6Na2O5
For Use With (Application) Cancer-Kinase/protease
Synonym Disodium (R)-2-hydroxyglutarate
Solubility Information H2O : 75 mg/mL (390.46 mM; Need ultrasonic)
SMILES O=C(O[Na])[C@H](O)CCC(O[Na])=O
Molecular Weight (g/mol) 192.08
Formula Weight 192.08
Percent Purity 95.0%
Grade Research
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