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Concanavalin A, MP Biomedicals™

Product Code. 11492082 Shop All MP Biomedicals Products
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500 mg
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Product Code. 11492082 Supplier MP Biomedicals Supplier No. 02150710.2

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Description

Isolated by affinity chromatography on cross-linked dextran. Concanavalin A, MP Biomedicals is pure Canavalia ensiformis lectin (Con A) from Jackbean. It exists as a dimer below pH 5.0, and at pH >7, it exists as a tetramer.

Lectin are used in a wide variety of applications. Con-A is not a glycoprotein and does not contain cysteine residues. Unlike most other lectins, Con-A is a metalloprotein and requires a transition metal ion, such as manganese, plus calcium ions for binding.

  • Con A is not blood group specific but has an affinity for terminal α-D-mannosyl and α-D-glucosyl residues. Con-A binds specifically to mannosyl and glucosyl residues of polysaccharides and glycoproteins.
  • Unmodified hydroxyl groups at the C3, C4 and C6 positions of D-glucopyranosyl or D-mannopyranosyl rings may be essential for binding.
  • Each subunit of Con A contains one calcium ion and one manganese ion. Removal of these cations by dialysis under acidic conditions abolishes the carbohydrate-binding activity.
  • Con A dissociates into dimers at pH 5.6 or below. Between pH 5.8 and pH 7.0, Con A exists as a tetramer. Above pH 7.0 higher aggregates are formed.
  • Con A exhibits mitogenic activity which is dependent on its degree of aggregation. Succinylation results in an active dimeric form which remains a dimer above pH 5.6.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 11028-71-0
Synonym Con A

Specifications

Quantity 250 mg
Solubility Information Soluble in water (10mg/mL, slightly hazy, colorless solution).
Formula Weight Monomeric molecular weight of Con-A is 25,500(Lit.)
Physical Form Powder

Safety and Handling

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Signal Word
  • Danger
 Hazard Category
  • Respiratory sensitiser Category 1
  • Reproductive toxicity Category 2
  • Skin sensitiser Category 1
 Hazard Statement
  • H334-May cause allergy or asthma symptoms or breathing difficulties if inhaled.
  • H361-Suspected of damaging fertility or the unborn child.
  • H317-May cause an allergic skin reaction.
 Precautionary Statement
  • P101-If medical advice is needed, have product container or label at hand.
  • P102-Keep out of reach of children.
  • P103-Read label before use.
  • P261-Avoid breathing dust/fume/gas/mist/vapours/spray.
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P284-¢In case of inadequate ventilation! wear respiratory protection.
  • P342+P311-If experiencing respiratory symptoms: Call a POISON CENTER/doctor/ .
  • P405-Store locked up.
  • P501-Dispose of contents/container to in accordance with local/regional/national/international regulations.
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