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Clozapine, MedChemExpress

Product Code. 16456486
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Product Code. 16456486 Supplier Medchem Express Supplier No. HY14539
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Estimated Shipment: 07-12-2026
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Description

MedChemExpress Clozapine (HF 1854) is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a Ki of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with Kis of 9.5 nM and 4 nM, respectively. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM).

Clozapine (HF 1854) is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a Ki of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with Kis of 9.5 nM and 4 nM, respectively. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM).

Specifications

Chemical Name or Material Clozapine
CAS 5786-21-0
Color Light Yellow
Purity Grade Notes Research
Molecular Formula C18H19ClN4
Quantity 100 mg
Synonym HF 1854
Solubility Information DMSO : 50 mg/mL (152.99 mM; Need ultrasonic)
SMILES CN1CCN(CC1)C2=NC3=CC(Cl)=CC=C3NC4=CC=CC=C42
Molecular Weight (g/mol) 326.82
Formula Weight 326.82
Percent Purity 99.74%
Grade Research
Physical Form Solid
For Use With (Application) Neuroscience-Neurodegeneration
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Research purposes only

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