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  5. Tocris Bioscience™ Chroman 1

Tocris Bioscience™ Chroman 1

Product Code. p-7199105
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Product Code. Quantity unitSize
18709286 10 mg 10mg
18725466 50 mg 50mg
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Product Code. 18709286 Supplier Tocris Bioscience™ Supplier No. 7163/10

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Description

Highly potent and selective ROCK 2 inhibitor; improves cell survival after cryogeneisis

Chroman 1 is a highly potent and selective ROCK2 (Rho-kinase) inhibitor (IC50 values are 1 and 52 pM at ROCK2 and ROCK1, respectively). Chroman 1 exhibits >2000-fold selectivity for ROCK2 over a range of related kinases including MRCK, PKA, and AKT1 (IC50 values are 150, >20000, and >20000 nM, respectively). Chroman 1 promotes survival of pluripotent stem cells (PSCs) in culture when used in combination with Emricasan (Cat. No. 7310), Polyamines, and Trans-ISRIB (Cat. No. 5284), a combination known as CEPT. When used as part of the CEPT cocktail, Chroman 1 also improves survival of differentiated cells following cryopreservation with cardiomyocyte cell survival increasing by 36% and motor neuron survival improving by 63% compared with DMSO controls.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material (3 S)-N-[2-[2-(Dimethylamino)ethoxy]-4-(1 H-pyrazol-4-yl)phenyl]-3,4-dihydro-6-methoxy-2 H-1-benzopyran-3-carboxamide dihydrochloride
Quantity 10 mg
Target Rho-kinase Inhibitors
Molecular Formula C24H28N4O40.2 HCl
Formula Weight 3081
Purity 98%
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