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Description
Immunogen sequence: GSRDQEEGKN HMYLFEGKDY SKEPSKEDRK SFEQLVNLQK TLLEKASQEG RSLRNKGSVL IPGLVEGSTK RKRVLSPEEL EDRQKKRQEA AAKRRRLIEE KKR Highest antigen sequence identity to the following orthologs: Mouse - 76%, Rat - 78%.
In response to DNA strand breaks, chromatin adopts a relaxed structure due to the addition of poly(ADP-ribose) (PAR) to chromatin proteins by PARP enzymes (see PARP1; MIM 173870), and this relaxation facilitates the repair of DNA damage. CHD1L interacts with PAR and has a role in chromatin relaxation following DNA damage (Ahel et al., 2009 [PubMed 19661379]).
Specifications
Specifications
| Antigen | CHD1L |
| Applications | Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry |
| Classification | Polyclonal |
| Concentration | 0.50 mg/mL |
| Conjugate | Unconjugated |
| Formulation | PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 |
| Gene | CHD1L |
| Gene Accession No. | Q86WJ1 |
| Gene Alias | 4432404A22Rik; ALC1; amplified in liver cancer 1; amplified in liver cancer protein 1; CHD1L; CHDL; chromodomain helicase DNA binding protein 1 like; chromodomain helicase DNA binding protein 1-like; chromodomain-helicase-DNA-binding protein 1-like; LOW QUALITY PROTEIN: chromodomain-helicase-DNA-binding protein 1-like; Snf2p; Unknown (protein for MGC:128792) |
| Gene Symbols | CHD1L |
| Show More |
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