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Invitrogen™ CD68 Monoclonal Antibody (FA-11), Alexa Fluor™ 488, eBioscience™, Invitrogen™
Description
This FA-11 monoclonal antibody reacts with mouse CD68, known also as macrosialin. CD68 is a heavily O- and N- glycosylated type I integral membrane protein belonging to the sialomucin family and is closely related to the Lysosomal/endosomal-Associated Mem
CD68 (Macrosialin) is a 110 kDa integral membrane glycoprotein predominantly expressed on the intracellular lysomsomes of monocytes and macrophages and to a lesser extent by dendritic cells and peripheral blood granulocytes. Also, CD68 could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. CD68 is expressed by interdigitating reticulum cells in tonsil and some histiocytic lymphoma or histiocytosis, acute myeloid leukemia (AML), and granulocytic sarcoma. Elevated expression of CD68 has been demonstrated on CD34+ cells in various human malignancies, including several Acute Myeloid Leukemia studies.
Specifications
Specifications
| Antigen | CD68 |
| Applications | Flow Cytometry |
| Classification | Monoclonal |
| Clone | FA-11 |
| Concentration | 0.5 mg/mL |
| Conjugate | Alexa Fluor 488 |
| Formulation | PBS with 0.09% sodium azide; pH 7.2 |
| Gene | Cd68 |
| Gene Accession No. | P31996 |
| Gene Alias | CD68; CD68 antigen; CD68 molecule; GP110; Lamp4; macrophage antigen CD68; macrosialin; Scard1; scavenger receptor class D, member 1; similar to CD68 antigen |
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