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  6. Invitrogen™ CD59 Monoclonal Antibody (MEM-43), PE, Invitrogen™

Invitrogen™ CD59 Monoclonal Antibody (MEM-43), PE, Invitrogen™
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Product Code. 10680864
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Quantity:
500 μL
2 mL
Unit Size:
Each
Product Code. Quantity unitSize
10680864 500 μL Each
10303453 2 mL Each
2 options
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Product Code. 10680864

Brand: Invitrogen™ MHCD5904

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This item is not returnable. View return policy

Description

Mouse Monoclonal Antibody

R-phycoerythrin (PE) is a stable and highly soluble phycobiliprotein which provides maximal absorbance and fluorescence without susceptibility to internal or external fluorescence quenching, thus providing an exceptional quantum yields and molar extinction coefficients.

CD59 (Protectin) is a small (18-20 kDa) GPI-anchored ubiquitously expressed inhibitor of the membrane attack complex (MAC). CD59 is the key regulator that preserves the autologous cells from terminal effector mechanism of the complement cascade. CD59 also associates with C5b-8 complex and counteracts appropriate formation of cytolytic pore within the plasma membrane. Further, CD59 is a low-affinity ligand of human CD2, causes T cell costimulation, and is involved in lymphocyte signal transduction. CD59 is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. Mutations in this gene cause CD59 deficiency, a disease involving hemolytic anemia, thrombosis, and cerebral infarction. Multiple alternatively spliced transcript variants of CD59 have been identified.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CD59
Applications Flow Cytometry
Classification Monoclonal
Clone MEM-43
Concentration 0.1mg/mL
Conjugate PE
Description CD59 Monoclonal Antibody, 0.5mL, 0.1mg/mL Concentration, MEM-43 Clone, CD59 Antigen, Human CD59 Immunogen, Mouse Host, Human Reactivity, PE Conjugate, IgG2a Isotype, Used For Flow Cytometry
Dilution Assay-dependent
Formulation PBS with 4mg/mL BSA, 10% sucrose and 0.1% sodium azide
Gene CD59
Gene Accession No. P13987
Gene Alias 16.3A5; 1F5; 1F5 antigen; 20 kDa homologous restriction factor; AA987121; Cb59b molecule; CD59; CD59 antigen; CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344); CD59 glycoprotein; CD59 molecule; CD59 molecule (CD59 blood group); CD59 molecule, complement regulatory protein; Cd59a; CD59a antigen; CD59A glycoprotein; Cd59b; CD59b antigen; CD59B glycoprotein; CD59b moleucle, complement regulatory protein; complement inhibitor CD59; complement regulatory protein; EJ16; EJ30; EL32; G344; HRF20; HRF-20; human leukocyte antigen MIC11; Ly-6-like protein; lymphocytic antigen CD59/MEM43; MACIF; MAC-inhibitory protein; MACIP; MAC-IP; MEM43; MEM43 antigen; membrane attack complex (MAC) inhibition factor; membrane attack complex inhibition factor; Membrane inhibitor of reactive lysis; MIC11; MIN1; MIN2; MIN3; MIRL; MSK21; p18-20; protectin; surface anitgen recognized by monoclonal antibody 16.3A5; T cell-activating protein
Gene Symbols CD59
Host Species Mouse
Immunogen Human CD59.
Molecular Weight of Antigen 18 to 20kDa
Purification Method purified
Quantity 500 μL
Regulatory Status ASR
Primary or Secondary Primary
Gene ID (Entrez) 966
Packaging 1 Each
Includes 0.1% Sodium azide
Target Species Human
Content And Storage 4°C, store in dark
Product Type Antibody
Form Liquid
Isotype IgG2a
Green Features Responsibly packaged
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Analyte Specific Reagent. Analytical and performance characteristics are not established.

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