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IBA Lifesciences CD3/CD28 Streptamer™ Kit
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Product Code. 17247610

Brand: IBA Lifesciences 68900050

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Description

T cell activation and expansion with removable stimulation reagents

  • The CD3/CD28 Streptamer™ approach is based on our Strep-tag™ technology and facilitates T cell activation and expansion
  • Low affinity, Fab fragments fused to a Twin-Strep-tag™ (Fab-Streps) against CD3 and CD28 are multimerized on a Strep-Tactin™ backbone
  • The resulting CD3/CD28 Streptamer™ complex stimulates the T cell receptor/CD3 complex (TCR/CD3; signal 1) and the co-stimulatory molecule CD28 (signal 2)
  • Providing these two signals leads to efficient T cell activation and proliferation
  • For in vitro stimulation and activation, the soluble CD3/CD28 Streptamers are added to T cells
  • The addition of biotin reverses the multimerization and causes the dissociation of low affinity Fab fragments from the cells
  • Consequently, the termination of stimulation is possible at any point in time

Specifications

Target Species Human
For Use With (Application) For T Cell Activation and Expansion

For Research Use Only.

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