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Bafilomycin A1, MedChemExpress

Product Code. 16464376
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Quantity:
100 μg
Unit Size:
100µg
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Product Code. 16464376

Brand: Medchem Express HY100558

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Description

MedChemExpress Bafilomycin A1 (BafA1) is a specific and reversible inhibitor of vacuolar H+-ATPase (V-ATPase) with IC50 values of 4-400 nmol/mg. Bafilomycin A1, a macrolide antibiotic, is also used as an autophagy inhibitor at the late stage. Bafilomycin A1 blocks autophagosome-lysosome fusion and inhibits acidification and protein degradation in lysosomes of cultured cells. Bafilomycin A1 induces apoptosis.

Bafilomycin A1 (BafA1) is a specific and reversible inhibitor of vacuolar H+-ATPase (V-ATPase) with IC50 values of 4-400 nmol/mg. Bafilomycin A1, a macrolide antibiotic, is also used as an autophagy inhibitor at the late stage. Bafilomycin A1 blocks autophagosome-lysosome fusion and inhibits acidification and protein degradation in lysosomes of cultured cells. Bafilomycin A1 induces apoptosis.

Specifications

Chemical Name or Material Bafilomycin A1
Physical Form Powder
CAS 88899-55-2
Color White
Quantity 100 μg
Purity Grade Notes Research
Molecular Formula C35H58O9
For Use With (Application) Cancer-programmed cell death
Synonym BafA1
Solubility Information DMSO : 100 mg/mL (160.56 mM; Need ultrasonic) ∣H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
SMILES C[C@H]([C@](O[C@@H]1C(C)C)(C[C@@H](O)[C@@H]1C)O)[C@H](O)[C@@H]([C@](OC(/C(OC)=C/C(C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C2)=O)([H])[C@H](/C=C/C=C2\C)OC)C
Molecular Weight (g/mol) 622.83
Formula Weight 622.83
Percent Purity 95.0%
Grade Research
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Research purposes only

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