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Avanafil, MedChemExpress

Product Code. 16483507
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Product Code. 16483507 Supplier Medchem Express Supplier No. HY18252

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Description

MedChemExpress Avanafil (TA-1790) is a potent and selective phosphodiesterase-5 (PDE-5) inhibitor with IC50 values of 5.2 nM, 630 nM, 5700 nM, 6200 nM, 12000 nM, 27000 nM, 51000 nM and 53000 nM for PDE-5, PDE-6, PDE-4, PDE-10, PDE-8, PDE-7, PDE-2 and PDE-1, respectively.

Avanafil activates NO/cGMP/PKG signaling-pathway to decrease loss in BMD, bone atrophy, and oxidative stress. Avanafil inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Avanafil can be used for the research of erectile dysfunction and osteoporosis.

Specifications

Chemical Name or Material Avanafil
CAS 330784-47-9
Color White
Purity Grade Notes Research
Molecular Formula C23H26ClN7O3
Quantity 50 mg
Synonym TA1790
Solubility Information DMSO : 50 mg/mL (103.32 mM; Need ultrasonic)
SMILES COC1=C(Cl)C=C(CNC2=C(C(NCC3=NC=CC=N3)=O)C=NC(N4[C@H](CO)CCC4)=N2)C=C1
Molecular Weight (g/mol) 483.95
Formula Weight 483.95
Percent Purity 98.0%
Grade Research
Physical Form Solid
For Use With (Application) COVID-19-immunoregulation
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Research purposes only

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