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Apramycin sulfate

Product Code. 15408049
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Product Code. 15408049 Supplier Thermo Scientific Alfa Aesar Supplier No. J66616.03
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Description

Apramycin sulfate, CAS # 65710-07-8, is the salt of apramycin, the bacteriostatic aminoglycoside antibiotic. | CAS: 65710-07-8 | C21H43N5O15S | 637.66 g/mol

Apramycin sulfate binds to the deep groove of RNA and effectively inhibits ribosomal translocation prohibiting protein synthesis.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Apramycin is a 2-deoxysteptamine derivative and an aminoglycoside originally isolated from Streptomyces tenebrarius
• Apramycin sulfate is comprised of a bicyclic sugar moiety and a monosubstituted deoxystreptamine attached to a sulfate group

Application

• Apramycin sulfate exhibits antibiotic activity against gram-negative bacteria
• It is suitable for laboratory use against Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa
• It is also used for laboratory study of infectious disease

TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 65710-07-8
Molecular Formula C21H43N5O15S
Molecular Weight (g/mol) 637.66
MDL Number MFCD06200257
InChI Key WGLYHYWDYPSNPF-RQFIXDHTSA-N
Synonym Nebramycin II
PubChem CID 3081544
IUPAC Name (2R,3R,4S,5S,6S)-2-{[(2R,3S,4R,4aR,6S,7R,8aS)-7-amino-6-{[(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl]oxy}-4-hydroxy-3-(methylamino)-octahydropyrano[3,2-b]pyran-2-yl]oxy}-5-amino-6-(hydroxymethyl)oxane-3,4-diol; sulfuric acid
SMILES OS(O)(=O)=O.CN[C@H]1[C@@H](O)[C@H]2O[C@H](O[C@@H]3[C@@H](N)C[C@@H](N)[C@H](O)[C@H]3O)[C@H](N)C[C@@H]2O[C@@H]1O[C@H]1O[C@H](CO)[C@@H](N)[C@H](O)[C@H]1O

Specifications

Type Apramycin Sulfate
Physical Form Powder
Melting Point 168°C
Color Yellow
Quantity 1 g
Flash Point >110°C (230°F)
Boiling Point 823°C
Solubility Information Soluble in water at 25mg/ml
Formula Weight 637.65
Chemical Name or Material Apramycin sulfate

Safety and Handling

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Product Identifier
  • Apramycin sulphate
 Signal Word
  • Danger
 Hazard Category
  • Serious eye damage/eye irritation Category 2
  • Reproductive toxicity Category 1A
  • Skin corrosion/irritation Category 2
 Hazard Statement
  • H315-Causes skin irritation.
  • H319-Causes serious eye irritation.
  • H360-May damage fertility or the unborn child.
 Precautionary Statement
  • P201-Obtain special instructions before use.
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P302+P352-IF ON SKIN: Wash with plenty of water/.
  • P308+P313-IF exposed or concerned: Get medical advice/attention.
  • P332+P313-If skin irritation occurs: Get medical advice/attention.
 Supplemental information
  • MIXTURE LIST-Contain: Apramycin sulphate
SDS

RUO – Research Use Only

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