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c-Myc with control Mouse anti-Human, Unlabeled, Clone: 9E10., BD
Mouse Monoclonal Antibody
250.08 EUR - 420.15 EUR
Specifications
| Antigen | c-Myc with control |
|---|---|
| Clone | 9E10. |
| Applications | Western Blot |
| Classification | Monoclonal |
| Conjugate | Unconjugated |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
15826528
|
BD Biosciences
551101 |
50 μg |
 251.00 EUR 250.08 EUR / Each Save 0.92 EUR 0.37% Off |
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|
15836528
|
BD Biosciences
551102 |
150 μg |
421.00 EUR 420.15 EUR / Each Save 0.85 EUR 0.20% Off |
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Description
The myc gene family contains at least seven closely related genes, c-myc, N-myc, L-myc, P-myc, R-myc, S-myc, and B-myc. C-myc plays a role in proliferation, transformation, and differentiation. It is expressed during embryonic development, in a wide variety of adult tissues, and is amplified in many tumors, particularly lung, breast, cervical and colon carcinomas. Cellular localization has been described as nuclear and/or cytopasmic. C-myc has three sequence motifs in the carboxy terminus, a leucine zipper, a helix-loop-helix, and a basic region. It forms sequence-specific (CACGTG) DNA binding heterodimers with max, a helixloop-helix/leucine zipper protein. Both the leucine zipper domain and the helixloop-helix motif of c-myc contribute to heterodimer formation. DNA binding of myc-max dimers results in a conformational change of the DNA and transcriptional activation. C-myc migrates at 62 kDa in SDS-PAGE. Clone 9E10 recognizes human c-myc. A synthetic peptide corresponding to a C-terminal epitope of the human c-myc protein (AEEQKLISEEDL) was used as an immunogen.
Specifications
| c-Myc with control | |
| Western Blot | |
| Unconjugated | |
| RUO | |
| IgG1 | |
| Affinity Purified |
| 9E10. | |
| Monoclonal | |
| Mouse | |
| Human | |
| Primary | |
| Store undiluted at -20°C. |
For Research Use Only.
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