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c-Myc with control Mouse anti-Human, Unlabeled, Clone: 9E10., BD

Product Code. 15826528
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50 μg
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15826528 50 μg Each
15836528 150 μg Each
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Product Code. 15826528 Supplier BD Biosciences Supplier No. 551101

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Mouse Monoclonal Antibody

The myc gene family contains at least seven closely related genes, c-myc, N-myc, L-myc, P-myc, R-myc, S-myc, and B-myc. C-myc plays a role in proliferation, transformation, and differentiation. It is expressed during embryonic development, in a wide variety of adult tissues, and is amplified in many tumors, particularly lung, breast, cervical and colon carcinomas. Cellular localization has been described as nuclear and/or cytopasmic. C-myc has three sequence motifs in the carboxy terminus, a leucine zipper, a helix-loop-helix, and a basic region. It forms sequence-specific (CACGTG) DNA binding heterodimers with max, a helixloop-helix/leucine zipper protein. Both the leucine zipper domain and the helixloop-helix motif of c-myc contribute to heterodimer formation. DNA binding of myc-max dimers results in a conformational change of the DNA and transcriptional activation. C-myc migrates at 62 kDa in SDS-PAGE. Clone 9E10 recognizes human c-myc. A synthetic peptide corresponding to a C-terminal epitope of the human c-myc protein (AEEQKLISEEDL) was used as an immunogen.

TRUSTED_SUSTAINABILITY

Specifications

Antigen c-Myc with control
Applications Western Blot
Classification Monoclonal
Clone 9E10.
Conjugate Unconjugated
Host Species Mouse
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Includes Purified Mouse Anti-Human c-Myc (50μg); Jurkat Cell Lysate (50μg)
Target Species Human
Content And Storage Store undiluted at -20°C.
Isotype IgG1
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For Research Use Only.

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