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Anhydrotetracycline hydrochloride

Product Code. 15468139
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Product Code. 15468139 Supplier Thermo Scientific Alfa Aesar Supplier No. J66688.MA
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Description

Anhydrotetracycline hydrochloride, CAS # 13803-65-1, is a tetracycline derivative showing antibacterial activity commonly used to control tetracycline-dependent gene expression systems in bacteria. | CAS: 13803-65-1 | C22H23ClN2O6 | 446.88 g/mol

Anhydrotetracycline hydrochloride acts as a useful effector of tetracycline-dependent gene expression in bacterial expression systems.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Anhydrotetracycline hydrochloride is a degradation product derived from tetracycline hydrochloride. It acts as an effector of tetracycline-dependent gene expression in bacterial expression systems. In this system the transcription of genes is reversibly turned on/off in the presence of several compounds including, anhydrotetracycline hydrochloride.
• This compound poorly binds to the 30S ribosomal subunit compared with its precursor, tetracycline.

Applications
• Anhydrotetracycline hydrochloride is commonly used in all fields of biology for control of transcription or translation processes
• This compound has been used in laboratory experiments and shows lower antibacterial activity against Escherichia coli compared with tetracycline.

TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 13803-65-1
Molecular Formula C22H23ClN2O7
Molecular Weight (g/mol) 462.89
MDL Number MFCD00151453
InChI Key FFZXKJVSZDKEMY-XGRJIHFXNA-N
PubChem CID 54710409
IUPAC Name hydrogen (2Z)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-11,12a-dihydroxy-6-methyl-1,2,3,4,4a,5,12,12a-octahydrotetracene-1,3,12-trione chloride
SMILES [H+].[Cl-].CN(C)C1C2CC3=C(C(O)=C4C=CC=CC4=C3C)C(=O)C2(O)C(=O)\C(=C(\N)O)C1=O

Specifications

Type Anhydrotetracycline Hydrochloride
Physical Form Crystalline Solid
Melting Point 220°C to 223°C
Color Yellow
Quantity 10 mg
Sensitivity Moisture sensitive
Beilstein 4228856
Solubility Information Soluble in ethanol, DMSO, or DMF
Formula Weight 462.88
Chemical Name or Material Anhydrotetracycline hydrochloride

Safety and Handling

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Product Identifier
  • Anhydrotetracycline hydrochloride
 Signal Word
  • Warning
 Hazard Category
  • Serious eye damage/eye irritation Category 2
  • Reproductive toxicity Category 2
 Hazard Statement
  • H319-Causes serious eye irritation.
  • H361d-Suspected of damaging the unborn child.
 Precautionary Statement
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P308+P313-IF exposed or concerned: Get medical advice/attention.
 Supplemental information
  • MIXTURE LIST-Contain: Anhydrotetracyclinehydrochloride
SDS

RUO – Research Use Only

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