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AMG-47a, MedChemExpress

Product Code. 16489977
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Product Code. 16489977

Brand: Medchem Express HY18303

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Description

MedChemExpress AMG-47a is a potent and orally active lymphocyte-specific protein tyrosine kinase (Lck) inhibitor, with an IC50 of 0.2 nM. AMG-47a also inhibits VEGF2, p38α, Jak3 and MLR and IL-2 with IC50s of 1 nM, 3 nM, 72 nM, 30 nM and 21 nM, respectively. AMG-47a has anti-inflammatory activity.

AMG-47a is a potent and orally active lymphocyte-specific protein tyrosine kinase (Lck) inhibitor, with an IC50 of 0.2 nM. AMG-47a also inhibits VEGF2, p38α, Jak3 and MLR and IL-2 with IC50s of 1 nM, 3 nM, 72 nM, 30 nM and 21 nM, respectively. AMG-47a has anti-inflammatory activity.

Specifications

Chemical Name or Material AMG-47a
Physical Form Solid
CAS 882663-88-9
Color Light Yellow
Quantity 5 mg
Purity Grade Notes Research
Molecular Formula C29H28F3N5O2
For Use With (Application) COVID-19-immunoregulation
Solubility Information DMSO : ≥ 34 mg/mL (63.48 mM)
SMILES O=C(NC1=CC=CC(C(F)(F)F)=C1)C2=CC=C(C)C(C3=CC4=CN=C(NCCN5CCOCC5)N=C4C=C3)=C2
Molecular Weight (g/mol) 535.56
Formula Weight 535.56
Percent Purity 98.72%
Grade Research
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Research purposes only

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