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Almorexant hydrochloride, MedChemExpress

Product Code. 16486877
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Product Code. 16486877 Supplier Medchem Express Supplier No. HY10805A

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Description

MedChemExpress Almorexant (ACT 078573) hydrochloride is an orally active, potent and competitive dual orexin receptor antagonist, with Kd values of 1.3 nM (OX1) and 0.17 nM (OX2), respectively.

Almorexant hydrochloride reversibly blocks signaling of orexin-A and orexin-B peptides. Almorexant hydrochloride totally blocked the intracellular Ca2+ signal pathway. Almorexant hydrochloride stimulates caspase-3 activity in AsPC-1 cells and induces apoptosis.

Specifications

Chemical Name or Material Almorexant hydrochloride
CAS 913358-93-7
Color White
Purity Grade Notes Research
Molecular Formula C29H32ClF3N2O3
Quantity 5 mg
Synonym ACT 078573 hydrochloride
Solubility Information DMSO : ≥ 46 mg/mL (83.79 mM) ∣H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
SMILES CNC([C@@H](C1=CC=CC=C1)N2CCC3=CC(OC)=C(OC)C=C3[C@@H]2CCC4=CC=C(C(F)(F)F)C=C4)=O.Cl
Molecular Weight (g/mol) 549.02
Formula Weight 549.02
Percent Purity 99.28%
Grade Research
Physical Form Solid
For Use With (Application) Neuroscience-Neuromodulation
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Research purposes only

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