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Afatinib dimaleate, MedChemExpress

Product Code. 16473748
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Code produit. 16473748 Fournisseur Medchem Express Code fournisseur HY10261A

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Description

MedChemExpress Afatinib (BIBW 2992) dimaleate is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Afatinib dimaleate can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer.

Afatinib (BIBW 2992) dimaleate is an orally active, potent and irreversible dual specificity inhibitor of ErbB family (EGFR and HER2), with IC50 values of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Afatinib dimaleate can be used for the research of esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC) and gastric cancer.

Spécification

Chemical Name or Material Afatinib dimaleate
CAS 850140-73-7
Color White
Purity Grade Notes Research
Molecular Formula C32H33ClFN5O11
Quantity 10 mg
Synonym BIBW 2992MA2
Solubility Information H2O : 50 mg/mL (69.63 mM; Need ultrasonic) ∣DMSO : ≥ 35 mg/mL (48.74 mM)
SMILES O=C(NC1=C(C=C2C(C(NC3=CC(Cl)=C(C=C3)F)=NC=N2)=C1)O[C@H]4CCOC4)/C=C/CN(C)C.O=C(O)/C=C\C(O)=O.O=C(O)/C=C\C(O)=O
Molecular Weight (g/mol) 718.08
Formula Weight 718.08
Percent Purity 95.0%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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