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  8. ABT-737, MedChemExpress

ABT-737, MedChemExpress

Product Code. 16488138
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Product Code. 16488138 Supplier Medchem Express Supplier No. HY50907

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Description

MedChemExpress ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-xL and Bcl-w inhibitor with EC50s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. ABT-737 induces the disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic apoptotic pathway. ABT-737 induces autophagy and has the potential for acute myeloid leukemia (AML) research.

ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-xL and Bcl-w inhibitor with EC50s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. ABT-737 induces the disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic apoptotic pathway. ABT-737 induces autophagy and has the potential for acute myeloid leukemia (AML) research.

Specifications

Chemical Name or Material ABT-737
CAS 852808-04-9
Color Orange Red
Purity Grade Notes Research
Molecular Formula C42H45ClN6O5S2
Quantity 10 mg
Solubility Information DMSO : 50 mg/mL (61.47 mM; Need ultrasonic)
SMILES CN(CC[C@@H](NC1=CC=C(C=C1[N+]([O-])=O)S(NC(C2=CC=C(C=C2)N3CCN(CC3)CC4=CC=CC=C4C5=CC=C(C=C5)Cl)=O)(=O)=O)CSC6=CC=CC=C6)C
Molecular Weight (g/mol) 813.43
Formula Weight 813.43
Percent Purity 98.38%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-programmed cell death
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Research purposes only

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