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  7. A-317491, MedChemExpress

A-317491, MedChemExpress

Product Code. 16479197
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Product Code. 16479197 Supplier Medchem Express Supplier No. HY15568

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Description

MedChemExpress A-317491 is a potent, selective and non-nucleotide antagonist of P2X3 and P2X2/3 receptors, with Kis of 22, 22, 9, and 92 nM for hP2X3, rP2X3, hP2X2/3, and rP2X2/3, respectively. A-317491 is highly selective (IC50>10 μM) over other P2 receptors and other neurotransmitter receptors, ion channels, and enzymes. A-317491 reduces inflammatory and neuropathic pain by blocking P2X3 and P2X2/3 receptor-mediated calcium flux.

A-317491 is a potent, selective and non-nucleotide antagonist of P2X3 and P2X2/3 receptors, with Kis of 22, 22, 9, and 92 nM for hP2X3, rP2X3, hP2X2/3, and rP2X2/3, respectively. A-317491 is highly selective (IC50>10 μM) over other P2 receptors and other neurotransmitter receptors, ion channels, and enzymes. A-317491 reduces inflammatory and neuropathic pain by blocking P2X3 and P2X2/3 receptor-mediated calcium flux.

Specifikationer

Chemical Name or Material A-317491
CAS 475205-49-3
Color Pink
Purity Grade Notes Research
Molecular Formula C33H27NO8
Quantity 5 mg
Solubility Information DMSO : ≥ 47 mg/mL (83.10 mM) ∣H2O : < 0.1 mg/mL (insoluble)
SMILES O=C(C1=CC(C(N(CC2=CC=CC(OC3=CC=CC=C3)=C2)[C@H]4CCCC5=C4C=CC=C5)=O)=C(C(O)=O)C=C1C(O)=O)O
Molecular Weight (g/mol) 565.57
Formula Weight 565.57
Percent Purity 98.25%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-programmed cell death
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Research purposes only

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