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  6. TdB Labs AB 500 kDa FITC-dextran Sulfate Green Fluorophore

TdB Labs AB 500 kDa FITC-dextran Sulfate Green Fluorophore

Product Code. 30216252
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Quantity:
100 mg
1 g
Unit Size:
100mg
1g
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Product Code. 30216252

Brand: TdB Labs AB FDSS500_100mg

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Description

FITC-dextran sulfate 500 kDa is a green-fluorescent, highly sulfated macromolecule used in virus binding, electrostatic interaction studies, and macromolecular transport assays where strong negative charge is required.

  • Product Overview: FITC-dextran sulfates are highly sulfated dextran molecules covalently labeled with fluorescein isothiocyanate (FITC), combining strong negative charge with bright green fluorescence. Available in 4 kDa, 10 kDa, 40 kDa, and 500 kDa molecular weights, FITC-dextran Sulfates are ideal for permeability studies, barrier function assays, and molecular interaction research where anionic tracers are required.
  • Features:
    • Green Fluorescence: Excitation maximum at 495 nm and emission maximum at 519 nm, compatible with standard FITC filter sets.
    • Highly Sulfated Structure: Provides strong negative charge density, mimicking the behavior of naturally occurring polyanions like heparin.
    • Wide Molecular Weight Range: Offered at 4 kDa, 10 kDa, 40 kDa, and 500 kDa to match different permeability and diffusion model requirements.
    • Water-Soluble: Fully soluble in aqueous media, facilitating easy preparation for biological and analytical experiments.
    • Controlled Labeling and Consistency: Manufactured under strict specifications to ensure reproducible fluorescence intensity and sulfation degree across batches.
  • Benefits:
    • Reliable Permeability Probes: Ideal for studying transport properties across biological membranes, vascular barriers, and engineered tissues.
    • Electrostatic Interaction Research: Useful for investigating binding to cationic proteins, peptides, or biomaterials.
    • Modeling Charged Molecule Behavior: Acts as an analog for anionic macromolecules in studies of transport, adsorption, and separation.
    • Flexible Application Across Systems: Suitable for live-cell, tissue culture, microfluidics, and in vivo tracer studies.
    • Bright and Stable Fluorescence: Enables sensitive detection and quantitative analysis using fluorescence-based methods.
  • Applications:
    • Barrier Function Assays: Used to assess the integrity of epithelial and endothelial monolayers, including gut and blood-brain barrier models.
    • Vascular Permeability Studies: Applied to measure vascular leakiness under physiological and pathological conditions.
    • Charge-Dependent Binding Studies: Investigates interactions between anionic molecules and cationic surfaces or proteins.
    • Tracer Studies in Microfluidics and Perfusion Systems: Tracks the movement of charged molecules through engineered or natural channels.
    • Cell Culture and Tissue Engineering Models: Maps molecular diffusion and barrier formation in tissue constructs and organoids.
  • Technical Specifications:
    • Fluorescence: Excitation maximum at 495 nm, emission maximum at 519 nm.
    • Molecular Weights: 4 kDa, 10 kDa, 40 kDa, and 500 kDa.
    • Appearance: Light-sensitive, greenish dry powder, readily soluble in water.
    • Sulfation Level: High, typically 16 to 20% sulfur content, depending on grade.
  • Storage and Stability:
    • Store dry, protected from light, at 2°C to 8°C for maximum stability and fluorescence preservation.
    • Stable under recommended conditions for long-term storage and experimental reliability.
  • Packaging and Availability:
    • Supplied as dry powder, facilitating long shelf life and ease of storage.
    • Available in various pack sizes to support both small-scale experiments and larger research projects.

Specifications

Quantity 100 mg
Product Type Fluorescent Labeling Reagent
Molecular Weight (g/mol) 500 kDa
Label Type Other Labels or Dyes
Color Green
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