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  7. 5-(N,N-Hexamethylene)-amiloride, MedChemExpress

5-(N,N-Hexamethylene)-amiloride, MedChemExpress

Product Code. 16478077
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Product Code. 16478077 Supplier Medchem Express Supplier No. HY128067

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Description

MedChemExpress 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) derives from an amiloride and is a potent Na+/H+ exchanger inhibitor, which decreases the intracellular pH (pHi) and induces apoptosis in leukemic cells.

5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC50s of 3.91 μM and 1.34 μM, respectively.

Specifications

Chemical Name or Material 5-(N,N-Hexamethylene)-amiloride
CAS 1428-95-1
Color Light Yellow
Purity Grade Notes Research
Molecular Formula C12H18ClN7O
Quantity 5 mg
Synonym Hexamethylene amiloride HMA
Solubility Information DMSO : 100 mg/mL (320.75 mM; Need ultrasonic)
SMILES O=C(C1=NC(Cl)=C(N2CCCCCC2)N=C1N)NC(N)=N
Molecular Weight (g/mol) 311.77
Formula Weight 311.77
Percent Purity 98.0%
Grade Research
Physical Form Powder
For Use With (Application) Cancer-programmed cell death
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Research purposes only

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