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TdB Labs AB 20 kDa DEAE-dextran for Transfection in Gene Therapy Studies
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Quantity:
1 g
10 g
100 g
Unit Size:
100g
10g
1g
Description
- Product Overview: DEAE-dextran is a cationic, water-soluble polysaccharide modified with diethylaminoethyl groups. Known for its strong positive charge and high biocompatibility, DEAE-dextran is ideal for researchers and bioprocess engineers working with protein purification, nucleic acid complexation, or surface functionalization. Available across a wide molecular weight range to match different project needs.
- Key Features:
- Strong Cationic Properties: DEAE-modification provides consistent positive charge for robust binding to negatively charged biomolecules like proteins, DNA, and RNA.
- Flexible Molecular Weight Range: Offered from 4 kDa up to 2000 kDa, giving options for fine-tuning binding strength, diffusion, and separation in your application.
- High Solubility: Fully water-soluble powder allows rapid and easy preparation for chromatography, formulation, or complexation protocols.
- Batch-to-Batch Consistency: Tight control over molecular weight and functionalization ensures reliable results across experiments and production runs.
- Stable Storage: Dry powder format provides long shelf life without special storage conditions, helping to minimize lab downtime.
- Why Choose DEAE-dextran:
- For Protein Purification: DEAE-dextran is a proven choice for anion-exchange chromatography workflows, helping isolate or fractionate proteins under mild, biocompatible conditions.
- For Complexation and Binding Studies: Ideal for creating complexes with nucleic acids or proteins to study binding kinetics, surface adsorption, or biomolecular interactions.
- For Transfection Research: Historically used in mammalian cell DNA transfection experiments, DEAE-dextran still finds niche use where simple, non-viral gene delivery is studied.
- For Surface Modification: Researchers functionalizing surfaces (e.g., biosensors, biomaterials) benefit from DEAE-dextran's ability to introduce stable, positive surface charges.
- For Vaccine Adjuvant Studies: Studied as a component in veterinary vaccine formulations to enhance immune system targeting by improving antigen presentation.
- Typical Applications:
- Ion-exchange chromatography for proteins and nucleic acids
- Formation of electrostatic complexes for analytical and purification purposes
- Historical and research-based DNA transfection in mammalian cells
- Surface coating and modification in bioengineering projects
- Supportive studies in vaccine and adjuvant formulation development
- Technical Details:
- Molecular Weights: 4 kDa, 20 kDa, 40 kDa, 70 kDa, 150 kDa, 500 kDa, and 2000 kDa available.
- Charge Density: Approximately 0.1 to 0.2 DEAE groups per glucose unit (depending on the grade).
- Appearance: White to off-white dry powder, highly soluble in water.
- Storage and Handling:
- Store dry at room temperature in a sealed container to maintain stability.
- Protect from moisture to preserve full activity over long-term storage.
- Availability:
- Supplied as research-grade powder, suitable for laboratory use and pilot-scale process development.
- Available in small packs for R and D or bulk volumes for production environments.
Specifications
Specifications
| Cell Type | HEK293 |
| Format | Vial |
| Promoter | None (Promoterless) |
| Transfection Technique | Chemical Transfection |
| Species | Human |
| Product Type | Transfection Reagent |
| Quantity | 1 g |
| Sterility | Non-sterile |
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