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  5. TdB Labs AB Dextran Sulfate 20 kDa High Sulfate

TdB Labs AB Dextran Sulfate 20 kDa High Sulfate

Product Code. 30216255
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Quantity:
10 g
100 g
Unit Size:
100g
10g
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Product Code. 30216255

Brand: TdB Labs AB DB012_100g

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This item is not returnable. View return policy

Description

Dextran sulfate 20 kDa HS is a highly sulfated, mid-sized polymer used in cell culture, virology, and purification. Its strong negative charge enables virus inhibition, protein stabilization, and electrostatic interaction studies in biochemical systems.

  • Product Overview: Dextran sulfates are sulfated polysaccharides derived from dextran, available in a wide range of molecular weights from 5 kDa to 2000 kDa. Their strong negative charge and biocompatibility make them valuable in diverse research and industrial applications, including cell culture media optimization, virus inhibition studies, anticoagulant research, and chromatography.
  • Features:
    • Wide Molecular Weight Range: Offered from 5 kDa to 2000 kDa to meet specific requirements in cell culture, biochemical assays, and purification processes.
    • High Sulfation Level: Most grades provide a strong negative charge density ideal for binding positively charged biomolecules; lower sulfation options available for specialized applications requiring moderated interaction.
    • Water-Soluble: Easily dissolves in aqueous solutions, facilitating incorporation into cell media, assay buffers, and purification systems.
    • High Purity and Lot-to-Lot Consistency: Stringent manufacturing controls ensure consistent sulfation levels, molecular weight distribution, and performance.
    • Biocompatible: Suitable for use in cell-based assays and formulations requiring minimized cytotoxicity.
  • Benefits:
    • Enhanced Cell Growth and Stability: Dextran Sulfates are used to optimize media formulations, improving growth and productivity of CHO and other mammalian cell lines for bioproduction.
    • Effective Virus Inhibition: Their ability to block virus adsorption to host cells makes them valuable in antiviral research and assay development.
    • Support for Biopharmaceutical Production: Commonly used in industrial-scale bioreactors to enhance recombinant protein yields in clinical and research-grade media.
    • Controlled Ionic Interactions: Available in different sulfation levels to fine-tune binding strength in protein purification, chromatography, or diagnostic assays.
    • Low Endotoxin Content: Manufactured to ensure low endotoxin levels, making them compatible with sensitive biological applications.
    • Flexible Application Scope: Suitable for basic research, diagnostic assay development, pharmaceutical production, and vaccine manufacturing support.
  • Applications:
    • Cell Media Supplement: Added to serum-free or chemically defined media to support mammalian cell growth, particularly CHO cells, for recombinant protein and antibody production.
    • Virus Inhibition Assays: Used to study virus entry mechanisms and to screen antiviral compounds by preventing viral attachment to host cells.
    • Protein Binding Studies: Useful in studies of electrostatic protein-polysaccharide interactions and competition assays.
    • Chromatography and Purification: Employed as a stationary phase component or additive to modify ionic properties in protein and nucleic acid purification workflows.
    • Anticoagulant Research: Investigated as heparin analogs for anticoagulant properties in blood-contacting biomaterials and pharmaceutical formulations.
    • Drug Delivery Research: Used to study carrier systems for drug delivery, especially in nanoparticle formulations requiring charged surface properties.
  • Technical Specifications:
    • Molecular Weights: Offered at 5 kDa, 10 kDa, 20 kDa, 40 kDa, 70 kDa, 150 kDa, 500 kDa, and 2000 kDa standard options.
    • Sulfation Degree: Typically high, corresponding to a sulfur content of approximately 16 to 20%; lower sulfation grades available on request.
    • Appearance: Fine, water-soluble white to off-white powder, ready for immediate use after reconstitution.
  • Storage and Stability:
    • Stable for extended periods when stored dry in tightly sealed containers at ambient temperature.
    • Recommended to protect from moisture and prolonged exposure to light for optimal performance.
  • Packaging and Availability:
    • Supplied as dry powder to ensure long shelf life and easy handling in laboratory and industrial environments.
    • Available in a variety of packaging sizes, from small research quantities to bulk manufacturing volumes.

Specifications

Quantity 100 g
Physical Form Crystalline Powder
Color White to Almost-white
Product Type Reagent
Molecular Weight (g/mol) 20 kDa
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