CAS RN 1820565-69-2

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PIM-447 dihydrochloride, MedChemExpress

MedChemExpress PIM447 dihydrochloride (LGH447 dihydrochloride) is a potent, orally available, and selective pan-PIM kinase inhibitor, with Ki values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively. PIM447 dihydrochloride displays dual antimyeloma and bone-protective effects. PIM447 dihydrochloride induces apoptosis.

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Specifications

Molecular Weight (g/mol)	513.38
Color	Off-White
Physical Form	Solid
Chemical Name or Material	PIM-447 dihydrochloride
Grade	Research
SMILES	O=C(C1=NC(C2=C(F)C=CC=C2F)=C(F)C=C1)NC3=C([C@H]4C[C@@H](N)C[C@@H](C)C4)C=CN=C3.Cl.Cl
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	98.25%
CAS	1820565-69-2
Solubility Information	H2O : 50 mg/mL (97.39 mM; Need ultrasonic) ∣DMSO : ≥ 46.7 mg/mL (90.97 mM)
Synonym	LGH447 dihydrochloride
Purity Grade Notes	Research
Recommended Storage	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Shelf Life	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Molecular Formula	C₂₄H₂₅Cl₂F₃N₄O
Formula Weight	513.38

CAS RN 1820565-69-2

CAS RN 1820565-69-2

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