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  8. PIM-447 dihydrochloride, MedChemExpress

PIM-447 dihydrochloride, MedChemExpress

Product Code. p-200102149
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Product Code. 16493697

Brand: Medchem Express HY19322B

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Description

MedChemExpress PIM447 dihydrochloride (LGH447 dihydrochloride) is a potent, orally available, and selective pan-PIM kinase inhibitor, with Ki values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively. PIM447 dihydrochloride displays dual antimyeloma and bone-protective effects. PIM447 dihydrochloride induces apoptosis.

PIM447 dihydrochloride (LGH447 dihydrochloride) is a potent, orally available, and selective pan-PIM kinase inhibitor, with Ki values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively. PIM447 dihydrochloride displays dual antimyeloma and bone-protective effects. PIM447 dihydrochloride induces apoptosis.

Specifications

Chemical Name or Material PIM-447 dihydrochloride
CAS 1820565-69-2
Color Off-White
Purity Grade Notes Research
Molecular Formula C24H25Cl2F3N4O
Quantity 50 mg
Synonym LGH447 dihydrochloride
Solubility Information H2O : 50 mg/mL (97.39 mM; Need ultrasonic) ∣DMSO : ≥ 46.7 mg/mL (90.97 mM)
SMILES O=C(C1=NC(C2=C(F)C=CC=C2F)=C(F)C=C1)NC3=C([C@H]4C[C@@H](N)C[C@@H](C)C4)C=CN=C3.Cl.Cl
Molecular Weight (g/mol) 513.38
Formula Weight 513.38
Percent Purity 98.25%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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