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Tetrahydroisoquinolines

Organic heterocyclic compounds that consist of an isoquinoline ring with no double bonds; contains a benzene ring fused to a six-membered ring with one nitrogen atom and five carbon atoms.

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1 – 15 of 66 results
1

Hydrastine, MedChemExpress

MedChemExpress Hydrastine is a natural alkaloid which is present in Hydrastis canadensis and other plants of the ranunculaceae family.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 383.39
Color Light Yellow
Physical Form Solid
Chemical Name or Material Hydrastine
Grade Research
SMILES O=C1O[C@H]([C@@H]2N(C)CCC3=C2C=C(OCO4)C4=C3)C5=C1C(OC)=C(OC)C=C5
Percent Purity 99.0%
CAS 118-08-1
Solubility Information DMSO : 100 mg/mL (260.83 mM; Need ultrasonic)
Synonym (-)-β-Hydrastine (1R,9S)-β-Hydrastine
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C21H21NO6
Formula Weight 383.39
2

Tetrandrine, MedChemExpress

MedChemExpress Tetrandrine (NSC-77037; d-Tetrandrine) is a bis-benzyl-isoquinoline alkaloid, which inhibits voltage-gated Ca2+ current (ICa) and Ca2+-activated K+ current.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 622.75
Color White
Physical Form Powder
Chemical Name or Material Tetrandrine
Grade Research
SMILES COC1=CC(CCN(C)[C@@]2([H])CC3=CC(O4)=C(OC)C=C3)=C2C(OC5=C(OC)C=C6C([C@]([H])(CC7=CC=C4C=C7)N(C)CC6)=C5)=C1OC
For Use With (Application) Cancer-programmed cell death
Percent Purity 99.49%
CAS 518-34-3
Solubility Information DMSO : 5 mg/mL (8.03 mM; Need ultrasonic and warming)
Synonym NSC-77037 d-Tetrandrine
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C38H42N2O6
Formula Weight 622.75
3

Nuciferine, MedChemExpress

MedChemExpress Nuciferine is an antagonist at 5-HT2A (IC50=478 nM), 5-HT2C (IC50=131 nM), and 5-HT2B (IC50=1 μM), an inverse agonist at 5-HT7 (IC50=150 nM), a partial agonist at D2 (EC50=64 nM), D5 (EC50=2.6 μM) and 5-HT6 (EC50=700 nM), an agonist at 5-HT1A (EC50=3.2 μM) and D4 (EC50=2 μM) receptor.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 295.38
Color Off-White
Physical Form Solid
Chemical Name or Material Nuciferine
Grade Research
SMILES CN1CCC2=CC(OC)=C(OC)C3=C2[C@@]1([H])CC4=CC=CC=C34
For Use With (Application) Neuroscience-Neuromodulation
Percent Purity 99.66%
CAS 475-83-2
Solubility Information DMSO : 11.11 mg/mL (37.61 mM; Need ultrasonic)
Health Hazard 1 H302∣H315∣H319∣H335
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C19H21NO2
Formula Weight 295.38
4

Tetrabenazine Racemate, MedChemExpress

MedChemExpress Tetrabenazine Racemate (Ro 1-9569 Racemate) is a selective and reversible inhibitor of vesicular monoamine transporter-2 (VMAT-2).

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 317.42
Color Light Yellow
Physical Form Solid
Chemical Name or Material Tetrabenazine Racemate
Grade Research
SMILES O=C1C(CC(C)C)CN2CCC3=CC(OC)=C(OC)C=C3C2C1
For Use With (Application) Neuroscience-Neuromodulation
Percent Purity 98.0%
CAS 718635-93-9
Solubility Information DMSO : 50 mg/mL (157.52 mM; Need ultrasonic)
Synonym Ro 1-9569 Racemate
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C19H27NO3
Formula Weight 317.42
5

Nomifensine, MedChemExpress

MedChemExpress Nomifensine is a norepinephrine-dopamine reuptake inhibitor, increases the amount of synaptic norepinephrine and dopamine available to receptors by blocking the dopamine and norepinephrine reuptake transporters.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 238.33
Color Light Yellow
Physical Form Solid
Chemical Name or Material Nomifensine
Grade Research
SMILES NC1=CC=CC2=C1CN(C)CC2C3=CC=CC=C3
For Use With (Application) Neuroscience-Neuromodulation
Percent Purity 95.0%
CAS 24526-64-5
Solubility Information DMSO : ≥ 100 mg/mL (419.59 mM)
Health Hazard 1 H302
Synonym (±)-Nomifensin
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C16H18N2
Formula Weight 238.33
6

Salsolidine, MedChemExpress

MedChemExpress Salsolidine is a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A inhibitor.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 207.27
Color Yellow
Physical Form Solid
Chemical Name or Material Salsolidine
Grade Research
SMILES CC1NCCC2=C1C=C(OC)C(OC)=C2
For Use With (Application) Neuroscience-Neuromodulation
Percent Purity 95.0%
CAS 5784-74-7
Solubility Information DMSO : 50 mg/mL (241.23 mM; Need ultrasonic)
Health Hazard 1 H302∣H315∣H319∣H335
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C12H17NO2
Formula Weight 207.27
7

L-Praziquanamine, MedChemExpress

MedChemExpress L-Praziquanamine is a natural product.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 202.25
Color Off-White
Physical Form Solid
Chemical Name or Material L-Praziquanamine
Grade Research
SMILES O=C1CNC[C@@]2([H])N1CCC3=C2C=CC=C3
CAS 99746-73-3
Solubility Information DMSO : 100 mg/mL (494.44 mM; Need ultrasonic)
Synonym (+)-Praziquanamine
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C12H14N2O
Formula Weight 202.25
8

Tetrahydroberberine, MedChemExpress

MedChemExpress Tetrahydroberberine is an isoquinoline alkaloid isolated from corydalis tuber; has micromolar affinity for dopamine D(2) (pK(i) = 6.08) and 5-HT(1A) (pK(i) = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors (5-HT(1B), 5-HT(1D), 5-HT(3), and 5-HT(4); pK(i) < 5.00).

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 339.39
Color Yellow
Physical Form Solid
Chemical Name or Material Tetrahydroberberine
Grade Research
SMILES COC1=CC=C(CC23)C(CN2CCC(C3=C4)=CC5=C4OCO5)=C1OC
For Use With (Application) Neuroscience-Neuromodulation
Percent Purity 99.65%
CAS 522-97-4
Solubility Information DMSO : 25 mg/mL (73.66 mM; Need ultrasonic)
Synonym Canadine
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C20H21NO4
Formula Weight 339.39
9

(-)-Isocorypalmine, MedChemExpress

MedChemExpress (-)-Isocorypalmine (Tetrahydrocolumbamine), isolated from the crude base fraction of Corydalis chaerophylla, is a dopamine receptor ligand. Recombinant CYP719A21 displays strict substrate specificity and high affinity (Km=4.63 ± 0.71 μM) for (-)-Isocorypalmine.

ENCOMPASS_PREFERRED
10

GPR84 antagonist 8, MedChemExpress

MedChemExpress GPR84 antagonist 8 is a selective GPR84 antagonist.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 421.45
Color Light Yellow
Physical Form Solid
Chemical Name or Material GPR84 antagonist 8
Grade Research
SMILES O=C1N=C(OCC2OCCOC2)C=C3N1CCC4=C3C=CC(OCC5=NC=CC=C5)=C4
For Use With (Application) COVID-19-immunoregulation
Percent Purity 99.85%
CAS 1445846-30-9
Solubility Information DMSO : 5 mg/mL (11.86 mM; Need ultrasonic)
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C23H23N3O5
Formula Weight 421.45
11

TCV-309 chloride, MedChemExpress

MedChemExpress TCV-309 chloride is a potent and specific platelet activating factor (PAF) antagonist. TCV-309 chloride specifically inhibits PAF-induced aggregation of rabbit and human platelets, and [3H]PAF binding to rabbit platelet microsomes with IC50 values of 33 nM, 58 nM and 27 nM, respectively. TCV-309 chloride has beneficial effects in anaphylactic shock.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 629.97
Color Yellow
Physical Form Solid
Chemical Name or Material TCV-309 chloride
Grade Research
SMILES CCC[N+]1=CC(C(N(CCC(NCCOC(N2CC3=C(C=CC=C3)CC2)=O)=O)C4=CC=CC=C4)=O)=CC(Br)=C1.[Cl-]
For Use With (Application) Cancer-programmed cell death
Percent Purity 98.0%
CAS 121494-09-5
Solubility Information DMSO : ≥ 6.3 mg/mL (10.00 mM)
Purity Grade Notes Research
Recommended Storage 4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Shelf Life 4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Molecular Formula C30H34BrClN4O4
Formula Weight 629.97
12

Daurisoline, MedChemExpress

MedChemExpress Daurisoline is a hERG inhibitor and also an autophagy blocker.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 610.74
Color White
Physical Form Solid
Chemical Name or Material Daurisoline
Grade Research
SMILES OC1=CC2=C(C=C1OC)CCN(C)[C@@H]2CC3=CC=C(O)C(OC4=CC=C(C[C@H]5N(C)CCC6=C5C=C(OC)C(OC)=C6)C=C4)=C3
For Use With (Application) Cancer-programmed cell death
Percent Purity 98.45%
CAS 70553-76-3
Solubility Information DMSO : 100 mg/mL (163.74 mM; Need ultrasonic)
Synonym (R,R)-Daurisoline
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C37H42N2O6
Formula Weight 610.74
13

Nampt-IN-1, MedChemExpress

MedChemExpress Nampt-IN-1 (LSN3154567) is a potent and selective NAMPT inhibitor. Nampt-IN-1 inhibits purified NAMPT with an IC50 of 3.1 nM.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 419.49
Color Light Yellow
Physical Form Solid
Chemical Name or Material Nampt-IN-1
Grade Research
SMILES O=C(N1CCC(C=C(NS(CC(C)(C)O)(=O)=O)C=C2)=C2C1)COC3=CN=CC=C3
For Use With (Application) Cancer-Kinase/protease
Percent Purity 98.06%
CAS 1698878-14-6
Solubility Information DMSO : 250 mg/mL (595.96 mM; Need ultrasonic)
Synonym LSN3154567
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C20H25N3O5S
Formula Weight 419.49
14

Tetrabenazine, MedChemExpress

MedChemExpress Tetrabenazine (Ro 1-9569) is a reversible inhibitor of the vesicular monoamine transporter VMAT2 with the Kd value of 1.34 nM. Tetrabenazine can be used for research on diseases related to hyperactive movement disorders such as Huntington's disease.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 317.42
Color White
Physical Form Solid
Chemical Name or Material Tetrabenazine
Grade Research
SMILES O=C1[C@@H](CC(C)C)CN2CCC3=CC(OC)=C(OC)C=C3[C@]2([H])C1.[relative stereochemistry]
For Use With (Application) Neuroscience-Neuromodulation
Percent Purity 98.0%
CAS 58-46-8
Solubility Information DMSO : 33.33 mg/mL (105.00 mM; Need ultrasonic) ∣H2O : < 0.1 mg/mL (ultrasonic) (insoluble)
Health Hazard 1 H302
Synonym Ro 1-9569
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C19H27NO3
Formula Weight 317.42
15

RP-54745, MedChemExpress

MedChemExpress RP-54745 is an inhibitor of macrophage stimulation and interleukin-1 production, and a potential antirheumatic compound.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 297.82
Color Light Yellow
Physical Form Solid
Chemical Name or Material RP-54745
Grade Research
SMILES O=C1SSC(N2C(C)C3=C(C=CC=C3)CC2)=C1Cl
For Use With (Application) COVID-19-immunoregulation
Percent Purity 99.93%
CAS 135330-08-4
Solubility Information DMSO : 62.5 mg/mL (209.86 mM; Need ultrasonic)
Health Hazard 1 H302∣H315∣H319∣H335
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C13H12ClNOS2
Formula Weight 297.82