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Description
ZNF496 contains a SCAN box, a KRAB-A domain, and four consensus C2H2-type zinc fingers preceded by a unique finger derivative, referred to herein as the C2HR motif. The C2HR motif functions to mediate protein-protein interaction with the cysteine-rich (C5HCH) domain of NSD1 in a Zn(II)-dependent fashion, and when tethered to RNA polymerase II promoters, represses transcription in an NSD1-dependent manner. ZNF496 contains a novel type of zinc finger motif that functions as a docking site for NSD1 and is more than just a degenerate evolutionary remt of a C2H2 motif.
Specifications
Specifications
| Antigen | ZNF496 |
| Applications | Western Blot |
| Classification | Polyclonal |
| Concentration | 0.63 mg/mL |
| Conjugate | Unconjugated |
| Formulation | PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 |
| Gene | ZNF496 |
| Gene Accession No. | Q5SXI5, Q96IT1 |
| Gene Alias | NIZP1, zinc finger protein 496, ZKSCAN17, ZNF496 |
| Gene Symbols | ZNF496 |
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Product Title
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